摘要
目的探讨女性不孕症因素中,自然、药物或人工终止妊娠导致不孕与原发不孕的差异。方法选取2007年1月至2009年12月于南京医科大学第一附属医院生殖医学中心拟行体外受精-胚胎移植(IVF-ET),而配偶精液常规检查结果正常的1753例女性不孕症患者为研究对象。按照是否流产,将其分为流产后不孕组(n=706)和原发不孕组(n=1047)(本研究遵循的程序符合本院人体试验委员会制定的伦理学标准,得到该委员会批准,分组征得受试对象本人的知情同意,并与其签署临床研究知情同意书)。对两组患者的一般临床资料[体重指数(BMI)、文化程度及不孕年限等]、导致不孕的病因和临床妊娠结局进行统计学分析。两组患者年龄比较,差异无统计学意义(P>0.05)。结果两组患者临床资料比较结果示:流产后不孕组的不孕年限较原发不孕组短,差异有统计学意义(P<0.05);两组患者BMI比较,差异无统计学意义(P>0.05);流产后不孕组文化程度比较,显著低于原发不孕组,差异有统计学意义(P<0.001)。导致不孕病因比较,流产后不孕组输卵管因素明显高于原发不孕组,差异有统计学意义(P<0.001);而排卵障碍、子宫内膜异位症、子宫及不明原因等因素比较,流产后不孕组则显著少于原发不孕组,且差异有统计学意义(P<0.001)。结论未生育妇女自然、人工或药物终止妊娠后导致不孕的主要病因为输卵管因素,文化程度偏低对不孕也有影响,故应加强对未生育妇女,尤其对文化程度较低人群的生殖健康相关知识的宣教,降低由于意外妊娠行终止妊娠术所引起的不孕症发生率。
Objective To study the difference between primary and postabortal （spontaneous, medical or artificial abortion） infertile women. Methods From January 2007 to December 2009,1753 women who underwent the treatment of in vitro fertilization and embryo transfer （IVF-ET） were included in the study, and were divided into postabortal infertile group （n = 706） and primary infertile group （n = 1047）. The general characteristics and infertile factors were analyzed in both groups. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of First Affiliated Hospital of Nanjing Medical University. Informed consent was obtained from each patient. There had no significant difference in age between two groups （P 〈0. 05）. Results The duration of infertility in postabortal infertile group was shorter than that in primary infertile group （P〈0.05）. There was no significant difference in body mass index （BMI） between two groups （P〉0.05）. The education level of patients in postabortal infertile group was significantly lower than that in primary infertile group（P〈0. 01）. Comparing to primary infertile group, the incidence of the tubal infertility was much higher than that in postabortal infertile group （P〈0. 001）. However, the incidence of infertility with ovulation failure, endometriosis, uterine and other factors in postabortal infertile group were significantly lower than those in primary infertile group （P〈 0. 001）. Conclusions The tubal factor was the major factor in the postabortal infertile women, especially those who with little education experience. We should pay more attention to the nonparous women and provide necessary information on reproductive health to them in order to decrease the incidence of infertility due to the unplanned pregnancy and abortion.
出处
《中华妇幼临床医学杂志（电子版）》
CAS
2012年第1期34-36,共3页
Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)
关键词
不孕
病因
自然
药物或人工终止妊娠
体外受精-胚胎移植
infertility
etiology
spontaneous, medical or artificial abortion
in vitrofertilization and embryo transfer
