摘要
目的探讨降脂平肝汤对非酒精性脂肪性肝病（NAFLD）患者降脂保肝作用的临床疗效。方法将2007年3月至2010年12月本院教职工常规体检筛查出的160例NAFLD患者按随机原则分为两组。每组80例。对照组患者口服氟伐他汀，每日1次，每次20mg。治疗组在对照组基础上加用自拟降脂平肝汤（基本方柴胡12g，白术15g，何首乌20g，枳实15g，赤芍15g，白芍15g，丹参15g，生山楂30g，泽泻20g，决明子20g，茯苓15g，甘草6g）随症加减，每日1剂。4周为1个疗程，观察3个疗程。治疗前后检测丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、总胆固醇（TC）、甘油三酯（TG）的变化并行肝脏超声检查。结果治疗后治疗组总有效率明显高于对照组（88.75％比77．50％，P〈0．05）；两组治疗后ALT（U／L）、AST（U／L）、TC（mmol／L）、TG（mmol／L）均较治疗前明显降低（对照组：ALT：56．26±5．22比84．12±5．37，AST：54．14±4．67比66．23±4．02，TC：6．87±2．01比7．98±1．16，TG：2．24±1．07比2．71±1．21；治疗组：AIT：34．31±5．32比86.26±3．06，AST：41．01±5．89比65．13±5．16，TC：5．92±1．02比8．06±1．03，TG：1.84±1．86比2．67±1．24），且以治疗组改善程度更显著（ALT：34．31±5．32比56．26±5．22，AST：41．01±5．89比54．14±4．67，TC：5．92±1．02比6．87±2．01，TG：1．84±1．86比2．24±1．07，均P〈0．05）。结论降脂平肝汤能明显降低NAFLD患者的血脂水平，保护肝功能，临床疗效显著。
Objective To discuss the clinical efficacy of decoction for lipid-lowering to calm liver on patients with nonalcoholic fatty liver （ NAFLD ） disease. Methods One hundred and sixty NAFLD patients screened from the routine heahh examination from March 2007 to December 2010 were randomly divided into two groups, each with 80 cases. Both groups took fluvastatin 20 mg orally once daily; the treatment group additionally took homemade decoction for lowering lipid to calm the liver （basic prescription： bupleurum Chinese 12 g, atractylodes 15 g, polygonum muhiflorum thunb 20 g, immature bitter orange 15 g, red peony root 15 g, white peony root 15 g, salvia mihiorrhiza 15 g, raw hawthorn 30 g, alisma 20 g, cassia seed 20 g, poria cocos 15 g, liquorice 6 g）, and according to the disease situation, the items in the prescription were regulated, one dose a day. Four weeks constituted one therapeutic course, and 3 therapeutic courses were for observation period. The changes of alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, total cholesterol （TC）, and triglyceride （TG）before and after treatment along with liver ultrasound inspection were checked. Results After treatment, the total therapeutic effect in treatment group was clearly better than that in control group （88.75% vs. 77.50% , P〈0.05） ; ALT （U/L）, AST （U/L）, TC （mmol/L） and TG （retool/L）in both groups were decreased obviously （control group： ALT： 56.26±5.22 vs. 84.12±5.37, AST： 54.14±4.67 vs. 66.23±4.02, TC： 6.87±2.01 vs. 7.98±1.16, TG： 2.24±1.07 vs. 2.71±1.21; treatment group： ALT： 34.31±5.32 vs. 86.26±3.06, AST： 41.01±5.89 vs. 65.13±5.16, TC： 5.92±1.02 vs. 8.06±_1.03, TG： 1.84±1.86 vs. 2.67± 1.24）, and the effectiveness in the treatment group was significantly higher than that in the control group （ALT： 34.31±5.32 vs. 56.26±5.22, AST： 41.01±5.89 vs. 54.14±4.67, TC： 5.92±1.02 vs. 6.87±2.01, TG： 1.84±1.86 vs. 2.24±1.07, all P〈0.05）. Conclusion Decoction for lowering lipid to calm the liver has remarkable clinical efficacy of regulating blood lipid and protecting liver function on NAFLD patients.
出处
《中国中西医结合急救杂志》
CAS
北大核心
2012年第1期26-28,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
黑龙江省医药卫生科研基金资助项目（2011-743）
关键词
降脂平肝汤
非酒精性脂肪性肝病
降脂
保肝
Decoction of lowering lipid to calm liver
Nonalcoholic fatty liver disease
Lipid-lowering
Liver protection
