摘要
目的 评估不同剂量瑞舒伐他汀对老年急性心肌梗死（AMI）患者室性心律失常（频发室性早搏和非持续性室性心动过速）的影响.方法 130例急性心肌梗死患者随机分为三组：A组43例,瑞舒伐他汀5 mg/d;B组45例,瑞舒伐他汀10 mg/d;C组42例,瑞舒伐他汀20 mg/d.入院后1～3 d应用Holter监测频发室性早搏（VPB）和非持续性室性心动过速（NSVT）.结果 C组发生VPB次数较A、B组明显减少（24 h,P＜0.01;72 h,P＜0.01）,NSVT的发生次数也明显少于其他两组（24 h,P＜0.01;72 h,P＜0.01）,A、B组VPB和NSVT发生次数差异无统计学意义（P＞0.05）.32例患者发生NSVT,大多为女性,既往有糖尿病、心肌梗死、心房颤动病史,LVEF＜40%,LVEDD＞55 mm,很少服用他汀类药物.治疗及随访期间三组患者均无明显的副作用出现.结论 老年急性心肌梗死患者早期应用20 mg/d瑞舒伐他汀能够明显减少室性早搏和非持续性室性心动过速的发生且安全性良好.
Objective To evaluate the effect of rosuvastatin with different doses on ventricular arrhythmias （frequent ventrleular premature and non-sustained ventricular tachycardia） in old patients with acute myocardial infarction. Methods 130 old patients with acute myocardial infarction were randomly divided into three groups： Groups A （with 5 mg/d rosuvastatin therapy, n=43 ）, Groups B （given 10 mg/d rosuvastatin therapy, n= 45）,Groups C （received 20 mg/d rosuvastatin therapy, n=42）. The frequency of ventricular premature beat （VPB） and non-sustained ventricular tachycardia （NSVT） was recorded via Holter monitoring after hospitalization （24 h and 72 h）. Results Ventrieular premature beats decreased significantly in the Groups C than the others （24 h, P〈0.01,72 h, P〈0.01）. Meanwhile, a significantly reduction in NSVT was seen in the Groups C （24 h, P〈0.01,72 h, P〈0.01）. But there had no significant differences between Groups A and Groups B in reducing vcntrieular arrhythmias （P〉0.05）. Thirty two patients had NSVT. When eompared to patients with no documented NSVT, patients with NSVT more fi＇equeney had diabetes mcllitus, myocardial infarction in their history, women, atrial fibrillation, an left ventricular ejection fraction （LVEF）〈40%, left ventricular dimension in diastolie （LVEDD）〉55 mm and few prior statin therapy. There were no side effeets observed in all groups during the hospitality and follow-up. Conclusion Early 20 mg/d rosuvastatin treatment not only ean elearly decrease VPB and NSVT but also has good security in elderly patients suffered from acute myocardial infarction.
出处
《中国心血管病研究》
CAS
2012年第1期38-42,共5页
Chinese Journal of Cardiovascular Research
关键词
急性心肌梗死
瑞舒伐他汀
室性心律失常
室性早搏
非持续性室性心动过速
老年
Acute myocardial infarction
Rosuvastatin
Ventricular arrhythmias
Ventricular premature beat
Non-sustained vcntricular taehyeardia
Elderly
