摘要
目的探讨丹红注射液对急性脑梗死患者神经功能及血清超敏C-反应蛋白（hs-CRP）、肿瘤坏死因子-α,（TNF-α）、白细胞介素。6（IL-6）的影响。方法按随机数字表法将80例急性脑梗死患者随机分为两组各40例，均给予阿司匹林、维生素E、维生素C等对症治疗。治疗组在此基础上加用丹红注射液静脉点滴，对照组加用低分子右旋糖苷、胞磷胆碱静脉点滴，均1次／d，14d为1个疗程。结果治疗后，患者的hs-CRP[治疗组（2．11±0．31）mg／L、对照组（2．72±0．23）mg／L]、TNF-α[治疗组（0．35±0．07）μg／L、对照组（0．51±0．06）μg／L]、IL-6[治疗组（18．17±3．15）μg／ml、对照组（28．13±4．97）μg／ml]均较同组治疗前降低（P〈0．05），治疗组下降程度较对照组更明显。两组患者的日常生活能力（ADL）[治疗组（20．26±2．17）分、对照组（28．83±2．93）分]及卒中量表（NIHSS）评分[治疗组（18．34±1．25）分、对照组（22．52±1．09）分]均较同组治疗前下降（P〈0．05），且治疗组下降更明显。结论丹红注射液配合对症治疗，可降低急性脑梗死患者血浆TNF-α、hs-CRP、IL-6水平，减轻神经功能缺损程度。
Objective To explore the influence of Danhong injection on neurological function and concentration level of high-sensitivity C-reactive protein （hs-CRP）, tumor necrosis factor alpha（TNF-α）, interleukin 6 （IL-6） in patients with acute cerebral infarction. Methods According to random number table method, eighty patients with acute cerebral infarction were randomly divided into a control group and a treatment gruop. Both groups were treated by aspirin, vitamine E, C and symptomatic treatment. At the same time, the treatment group was added Danhong injection, the control group was added low molecular dextran and citicoline, once a day, for 14 days. Results After the treatment, the concentration levels of hs-CRP [treatment group （2.11 ± 0.31） rag/L, control group （2.72 ± 0.23） rag/L], TNF-α [treatment group （0.35 ± 0.07） μg/L, control group （0.51 ± 0.06）μg/L], IL-6[treatment group （18.17 ±3.15） pg/ml, control group （28.13 ± 4.97） pg/ml]was significantly lower than those before the treatment in both groups （P〈0.05）. However, the concentration level of hs-CRP, TNF-α, IL-6 in treatment group was significantly lower than that in control group （P〈0.05）. ADL scores [treatment group （20.26±2.17） scores, control group （28.83±2.93） scores] and NIHSS scores [treatment group （18.34±1.25） scores, control group s （22.52± 1.09）cores] were significantly lower after treatment than those before the treatment in both groups （P〈0.05）, but all scores in treatment group were significantly lower than those in control group （P〈0.05）. Conclusion Danhong injection decreased the concentration level of hs-CRP, TNF-α, IL-6 and NIHSS scores, ADL scores significantly. It also alleviated neurological function defect, enhanced the patient＇s activities of daily living, and reduced the disability rate of isehemic brain damage.
出处
《国际中医中药杂志》
2012年第2期116-118,共3页
International Journal of Traditional Chinese Medicine
