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右美托咪啶辅助异丙酚靶控在宫腔镜黏膜下肌瘤电切术的有效性及安全性研究 被引量:12

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摘要 目的评价右美托咪啶复合异丙酚用于宫腔镜黏膜下肌瘤电切术的麻醉效果及安全性。方法美国麻醉师协会(ASA)Ⅰ或Ⅱ级需宫腔镜电切术患者50例,年龄25~40岁,随机分为右美托咪啶复合异丙酚组(Ⅰ组,n=25),异丙酚组(Ⅱ组,n=25)。Ⅰ组先缓慢静脉注射右美托咪啶1μg/kg,之后靶控输注异丙酚,Ⅱ组靶控输注异丙酚。对比2组扩宫与电切时异丙酚效应室浓度、异丙酚总用量、麻醉苏醒时间、呼吸抑制程度、恶心呕吐发生率、术后宫缩痛评分。结果Ⅰ组扩宫、电切时异丙酚效应室浓度及用药总量较Ⅱ组明显减少(P<0.05)。Ⅰ组术后宫缩痛发生率明显低于Ⅱ组(P<0.05),Ⅰ组术后恶心呕吐明显低于Ⅱ组(P<0.05)。结论缓慢静注右美托咪啶1μg/kg(>10min)复合异丙酚用于宫腔镜黏膜下肌瘤电切术,与单纯应用异丙酚比较,具有麻醉效果好、并发症少、术后镇痛完善的优点。
出处 《河北医药》 CAS 2012年第4期517-518,共2页 Hebei Medical Journal
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