摘要
目的了解新会地区病原菌分布及耐药流行趋势。方法 2007-2010年在新会区人民医院共分离7659株细菌,用ATB Expresion进行鉴定和药敏试验,并分析结果。结果临床分离的7659株细菌中球菌1632株占21.3%,杆菌4517株占59.0%,真菌1510株占19.7%。检出率在前五位的细菌分别为铜绿假单胞菌、白假丝酵母、大肠埃希氏菌、肺炎克雷伯菌肺炎亚种、金黄色葡萄球菌。未检测到耐万古霉素葡萄球菌。铜绿假单胞菌在2009-2010年成为检出率最高的细菌,其对亚胺培南(IMI)、美洛培南(MERO)的耐药率有所增加。大肠埃希氏菌、肺炎克雷伯菌肺炎亚种产ESBLs株比例较高,对广谱青霉素类和第三代头孢菌素耐药率高。真菌分离率较高,检出率排第二位。5-氟胞嘧啶(5-FC)、两性霉素B(AMB)可以作为抗真菌的首选药物。结论临床细菌分离总数有逐年增高趋势,应继续加强动态了解病原菌的分离率,以掌握本地区各类抗生素对各类细菌的敏感性和耐药性数据,帮助临床医生合理选择和应用抗生素,制定正确的抗感染治疗方案。
Objective To investigate the distribution and resistance of bacterial isolates collected in Xinhui area of Guangdong province.Methods 7 659 bacterial isolates collected in Xinhui Hospital Affiliated to Southern Medical University from 2007 to 2010 were subjected to identification and susceptibility testing by ATB Expresion.Results Of the 7 659 isolates,1 632（21.3%） were found to be cocci,4 517（59.0%） were bacilli,1 510（19.7%） were fungi.The top five bacteria identified were Pseudomonas aeruginosa,Candida albican,Escherichia coli,Klebsiella pneumoniae subsp.pneumoniae,Staphylococcus aureus.No vancomycin-resistant Staphylococcus aureus were detected.From 2009 to 2010,the detection rate of Pseudomonas aeruginosa was the highest,whose resistance to imipenem and meropenem increased.Escherichia coli,Klebsiella pneumoniae subsp.Pneumoniae had a higher production rate of ESBLs,which were highly resistant to broad-spectrum penicillins and the third-generation cephalosporins.The isolates detected second highest was Fungi,which highly sensitive to 5-fluorocytosine and Amphotericin B.Conclusion The number of bacteria isolated clinically were increased gradually every year.It is necessary for us to enhance our understanding on the distribution and resistance of pathogens,which provides guidance for the wise selection of antibiotics and treatment.
出处
《海南医学》
CAS
2012年第3期12-16,共5页
Hainan Medical Journal
关键词
抗菌药物
医院感染
病原菌
耐药性
Antimicrobial agent
Nosocomial infection
Pathogens
Resistance
