摘要
目的观察文拉法新缓释片与匹维溴铵联用治疗肠易激综合征的临床效果。方法将80例患者随机分为观察组和对照组,各40例,两组均用匹维溴铵50mg,每天3次,观察组同时加用文拉法新缓释片75mg/d,晚间顿服,疗程均为8周,观察临床疗效,并统计治疗前后两组HAMA、HAMD评分。结果观察组的消化道主要症状治疗后总有效率为95.00%;而对照组的总有效率为50.00%,组间比较P<0.01,治疗后观察组患者的HAMA、HAMD评分均显著低于对照组,差异有高度显著性(P<0.01)。结论文拉法新缓释片与匹维溴铵联用治疗肠易激综合征有较好效果,优于单用匹维溴铵组,两者具有协同作用,值得临床推广。
Objective To describe the clinicl results of venlafaxine extended-release tablets in combination with pinaverium bromide in treatment of irritable bowel syndrome.Methods 80 patients were randomly divided into two groups： the observation group and the control group,each group involved 40 patients.Patients in both two groups were given pinaverium bromide 50 mg,3 times a day;and venlafaxine extended-release tablets were added to the observation group,75mg a day,one tablet in the evening,both with a cycle of 8 weeks.The clinical results were observed and recorded.HAMA and HAMD scores before and after treatment in the two groups were compared statistically.Results In the observation group,the digestive symptoms could be ameliorated after treatment,the total effective rate was 95.00%;while in the control group,the total effective rate was 50.00%.In comparison of the total effective rate between the two groups,there was statistically significant difference（P0.01）.After treatment,the observation group in HAMA,HAMD scores were significantly lower than those in the control group,the difference was statistically significant（P〈0.01）.Conclusion The results of venlafaxine extended-release tablets in combination with pinaverium bromide in treatment of irritable bowel syndrome were satisfactory,which were superior to pinaverium bromide alone.The two has an intervened effect so it is worthy of recommendation.
出处
《右江民族医学院学报》
2012年第1期12-13,共2页
Journal of Youjiang Medical University for Nationalities
关键词
肠易激综合征
文拉法新缓释片
匹维溴铵
irritable bowel syndrome
venlafaxine extended-release tablets
pinaverium bromide
