摘要
目的:采用硅胶柱色谱、凝胶柱色谱Sephadex LH-20和MCI等各种柱色谱进行分离纯化,通过化合物的理化常数和波谱数据鉴定其结构。方法:采用硅胶柱色谱、凝胶柱色谱Sephadex LH-20和MCI等各种柱色谱进行分离纯化,通过化合物的理化常数和波谱数据鉴定其结构。结果:从曼陀罗种子的95%乙醇提取物中分离并鉴定了12个化合物,分别为N-trans-feruloyl tryptamine(1),hyoscyamilactol(2),东莨菪内酯(3),umckalin(4),曼陀罗萜醇酮(5),曼陀罗萜二醇(6),N-反式阿魏酰基酪胺(7),cleomiscosin A(8),秦皮素(9),东莨菪碱(10)1-acetyl-7-hydroxy-β-carboline(11),7-hydroxy-β-carboline1-propionic acid(12).结论:化合物2,7,9,12均为首次从曼陀罗属植物中分得;化合物1,4,8,11均为首次从茄科植物中分到。研究茄科Solanaceae植物曼陀罗Datura stramonium种子的化学成分。
Objective： To study chemical constituents in the seeds of Datura Stramonium （Solanaceae family）. Method： Compounds were isolated and purified by silica gel, MCI and Sephadex LH-20 column chromatography, and their structures were determined based on physicochemical constants and spectroscopic analysis including NMR and MS. Result： Twelve compounds were isola- ted and identified from Daturu stramonium, they were N-trans-feruloyl tryptamine （1） , hyoscyamilactol （2） , scopoletin （3）, umcka- lin （4）, daturaolone （5）, datnradiol （6）, N-trans-fernlicacyl-tyramine （7）, cleomiscosin A （8）, fraxetin （9）, scopolamine （10）, l-Acetyl-7-hydrox-β-carbol-ine （11）, 7-hydroxy-β-carbolinel-propionic acid （12）. Conclusion： Compound 2, 7, 9 and 12 were obtained from Datura genus for the first time, whereas compound 1, 4, 8 and 11 were obtained from the Solanaceae family for the first time.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2012年第3期319-322,共4页
China Journal of Chinese Materia Medica
关键词
曼陀罗属
曼陀罗
种子
化学成分
Datura
Datura stramonium
seed
chemical constituent
