摘要
The growing use of nanomaterials in commercial goods and novel technologies is generating increasing questions about possible risks for human health and environment, due to the lack of an in-depth assessment of their potential toxicity. In this context, we investigated the effects of citrate-capped gold nanoparticles （AuNPs） on the model system Drosophila melanogaster upon ingestion. We observed a significant in vivo toxicity of AuNPs, which elicited clear adverse effects in treated organisms, such as a strong reduction of their life span and fertility, presence of DNA fragmentation, as well as a significant overexpression of the stress proteins. Transmission electron microscopy demonstrated the localization of the nanoparticles in tissues of Drosophila. The experimental evidence of high in vivo toxicity of a nanoscale material, which is widely considered to be safe and biocompatible in its bulk form, opens up important questions in many fields, including nanomedicine, material science, health, drug delivery and risk assessment.
在商业商品和新奇技术的 nanomaterials 的成长使用正在产生为人的健康和环境关于可能的风险增加问题，由于对他们的潜在的毒性的一个深入的评价的缺乏。在这上下文，我们在摄取之上在模型系统果蝇 melanogaster 上调查了盖住柠檬酸盐的金 nanoparticles (AuNPs ) 的效果。我们观察了一在 vivo 毒性重要 AuNPs，在对待的有机体得到了清楚的不利效果，。传播电子显微镜学在果蝇的纸巾表明了 nanoparticles 的本地化。在 nanoscale 材料的 vivo 毒性的高度的试验性的证据，它是广泛地考虑了在它的体积表格是保险箱和 biocompatible，在许多领域，包括的 nanomedicine，材料科学，健康，药交货和风险里开创重要问题评价。
