摘要
目的探讨血液透析患者血清脂蛋白(a)与炎症标志物的变化及其相关性。方法 45例尿毒症血液透析患者分别在透析后测定血清脂蛋白(a)、CRP和IL-6含量。结果透析组脂蛋白(a)、CRP、IL-6含量增高了159.1%、54.5%和151.0%(P<0.01)。血液透析后,在CRP升高患者中,脂蛋白(a)和IL-6的含量较正常者分别增加91.6%和133.8%(P<0.01)。血液透析组患者的脂蛋白(a)含量与CRP和IL-6含量均呈显著的正相关。结论血液透析患者血清脂蛋白(a)与炎症标志物CRP、IL-6水平的变化有显著的相关性。
Objective To explore the changes of serum lipoprotein-a（Lp（a）） and inflammatory markers in patients with hemodialysis.and the relationship of them Methods 45 uremia cases with hemodialysis were selected and measured the serum Lp（a）,C-reactive protein（CRP） and interleukin-6（IL-6） before and after hemodialysis.Results After hemodialysis,the levels of Lp（a）,CRP and IL-6 were increased by 159.1%,54.5%,151.0% respectively（P0.01）.compared with the those who with nomal CRP level,the level of Lp（a） and IL-6 in patients with higher CRP level increased by 91.6%and 133.8%（P0.01） repectively.The levels of Lp（a）,CRP and IL-6 in hemodialysis patients were significantly positively correlated.Conclusion The serum lipoprotein（a） level is significantly correlated with inflammatory markers CRP,IL-6 levels in hemodialysis patients.
出处
《中国实用医药》
2011年第36期41-43,共3页
China Practical Medicine
