摘要
目的研究脓毒症患者血浆可溶性白细胞分化抗原14(sCD14)的动态变化及其临床意义。方法选择北京朝阳医院急诊重症监护病房2009年8月—2010年3月脓毒症患者60例,另选20名健康正常人为对照组。脓毒症组根据多脏器功能不全综合征(MODS)临床诊断标准分为MODS(33例)和非MODS(27例)两个亚组。脓毒症组在明确诊断后第1、3、7天检测血浆sCD14的水平并且计算患者当天的APACHEⅡ评分。结果与正常对照组相比,脓毒症组血sCD14浓度显著升高(P<0.01);MODS组血sCD14浓度[(5.3±2.4)mg/L]与非MODS组sCD14浓度[(3.8±2.8)mg/L]比较明显升高(P<0.05);MODS组APACHEⅡ评分较非MODS组升高(P<0.05);血sCD14浓度与APACHEⅡ评分具有正相关(P<0.05)。结论脓毒症患者血浆中sCD14升高,sCD14浓度较高的患者APACHEⅡ评分较高,病情危重。
Objective To explore the soluble cluster of differentiation antigen 14 （sCD14） dynamic changes and clinical significance on patients with sepsis. Methods Sixty patients were diagnosed with sepsis according to the di- agnosis criterions and selected as sepsis group from the emergency intensive care unit of Chaoyang Hospital affiliated Capital Medical University during the period from August 2009 to March 2010. 20 healthy persons were chosen as control group. Sepsis group was divided into multiple organ dysfunction syndrome （MODS） and non-MODS two subgroups according to MODS clinical diagnosis criterions, sCD14 concentration was detected and APACHE Ⅱ score were calculated on 1st, 3rd and 7th days after the patients were diagnosed sepsis in sepsis group. Results Com- pared with control group, sCD14 concentration was obviously higher in sepsis group （ P 〈 0. 01 ）. Compared with non-MODS subgroup, MODS subgroup has more higher sCD14 concentration [ （5.3 ± 2. 4 ） vs （3.8 ± 2. 8 ） mg/L, P 〈 0. 05 ] and APACHE Ⅱ scores （ P 〈 0. 05 ）. sCD14 concentration and APACHE Ⅱ scores had correlation （P 〈 0. 05）. Conclusion sCD14 concentration was high on patients with sepsis. MODS patients had high sCD14 concentration and APACHE Ⅱ scores, patients condition were more critical.
出处
《基础医学与临床》
CSCD
北大核心
2012年第2期207-210,共4页
Basic and Clinical Medicine
