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转录因子环腺苷酸反应元件结合蛋白介导的细胞凋亡及其调控机制 被引量：3

Cell apoptosis mediated by the transcription factor cAMP response element binding protein and its regulatory mechanism
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摘要 细胞凋亡是一个精细而复杂的过程,需要一系列的蛋白参与。其中环腺苷酸反应元件结合蛋白(CREB)作为一个核转录因子,通过自身磷酸化实现调节转录功能,改变细胞内的信号转导途径,从而调控细胞凋亡过程。我们结合研究结果对CREB介导的细胞凋亡及其调控机制作一综述。 Cell apoptosis is a complex and precise adjustment process, which involves numerous signal proteins. cAMP response element binding protein （CREB） , a transcriptional regulation factor in eucaryotic cell, regulates the cell apoptosis through changing the intracellular signal transduction by its phosphorylation, which is a pop research in recent years. In this review, recent progress in studying the regulatory effects of transcription factor CREB on cell apoptosis is briefly summarized.
作者 李垒 王萍
机构地区 宁波大学医学院人体解剖学与组织胚胎学系
出处 《解剖学报》 CAS CSCD 北大核心 2012年第1期139-144,共6页 Acta Anatomica Sinica
基金 国家自然科学基金资助项目(81071653) 浙江省自然科学基金资助项目(Y2111136) 宁波市自然科学基金资助项目(2011A610050)
关键词 环腺苷酸反应元件结合蛋白 信号通路 cAMP response element binding protein Signal transduction
分类号 R329 [医药卫生—人体解剖和组织胚胎学]
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参考文献40

  • 1Yin JC,Del Vecchio M,Zhou H,et al.CREB as a memory modulator:induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila[J].Cell,1995,81(1):107-115.
  • 2Persengiev SP,Green MR.The role of ATF/CREB family members in cell growth,survival and apoptosis[J].Apoptosis,2003,8(3):225-228.
  • 3张澄,王萍.转录因子CREB对细胞周期调控机制的研究进展[J].中国细胞生物学学报,2011,33(5):577-583. 被引量：12
  • 4Thornberry NA,Lazebnik Y.Caspases:enemies within[J].Science,1998,281(5381):1312-1316.
  • 5Inohara N,Koseki T,Hu Y,et al.CLARP,a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis[J].Proc Natl Acad Sci USA,1997,94(20):10717-10722.
  • 6Wang P,Xu J,Zhang C.CREB,a possible upstream regulator of Bcl-2 in trichosanthin-induced HeLa cell apoptosis[J].Mol Biol Rep,2010,37(4):1891-1896.
  • 7Francois F,Godinho MJ,Grimes ML.CREB is cleaved by caspases during neural cell apoptosis[J].FEBS Lett,2000,486(3):281-284.
  • 8Eliseev RA,Vanwinkle B,Rosier RN,et al.Diazoxide-mediated preconditioning against apoptosis involves activation of cAMP-response element-binding protein (CREB) and NFkappaB[J].J Biol Chem,2004,279(45):46748-46754.
  • 9Mori N,Fujii M,Cheng G,et al.Human T-cell leukemia virus type I tax protein induces the expression of anti-apoptotic gene Bcl-xL in human T-cells through nuclear factor-kappaB and c-AMP responsive element binding protein pathways[J].Virus Genes,2001,22(3):279-287.
  • 10豆长明,李继承.天花粉蛋白对HepA-H细胞和HeLa细胞抑癌活性研究[J].中国病理生理杂志,2005,21(5):980-984. 被引量：13

二级参考文献83

  • 1戴荣禧,徐国江,刘莲英,林秀媛,沈慧屏,周筱刚,高彤,王亚辉.天花粉蛋白对滋养层细胞专一损伤机制的研究[J].实验生物学报,1993,26(4):411-427. 被引量：14
  • 2Lolli G, Johnson LN. CAK-cyclin-dependent activating kinase: A key kinase in cell cycle control and a target for drugs? Cell Cycle 2005; 4(4): 572-7.
  • 3Nakayama KI, Nakayama K. Ubiquitin ligases: cell-cycle control and cancer. Nat Rev Cancer 2006; 6(5): 369-81,.
  • 4Morgan DO. Regulation of the APC and the exit from mitosis. Nat Cell Biol 1999; 1(2): E47-53.
  • 5Arany Z, Newsome D, Oldread E, Livingston DM, Eckner R.A family of transcriptional adaptor proteins targeted by the EIA oncoprotein. Nature 1995; 374(6517): 81-4.
  • 6Lundblad JR, Kwok RP, Laurance ME, Harter ML, Goodman RH. Adenoviral ElA-associated protein p300 as a functional homologue of the transcriptional co-activator CBP. Nature 1995; 374(6517): 85-8.
  • 7Das C, Lucia MS, Hansen KC, Tyler JK. CBP/p300-mediated acetylation of histone H3 on lysine 56. Nature 2009; 459(7243): 113-7.
  • 8Chan HM, La Thangue NB. p300/CBP proteins: HATs for tran- scriptional bridges and scaffolds. J Cell Sci 2001; 114(Pt 13): 2363-73.
  • 9Muraoka M, Konishi M, Kikuchi-Yanoshita R, Tanaka K, Shitara N, Chong JM, et al. p300 gene alterations in colorectal and gastric carcinomas. Oncogene 1996; 12(7): 1565-9.
  • 10Major ML, Lepe R, Costa RH. Forkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivators. Mol Cell Biol 2004; 24(7): 2649-61.

共引文献34

同被引文献59

  • 1Bravu-Cordero J J, Hodgson L, Condeelis J. Directed cell invasion and migration during metastasis[ J ]. Curt Opin Cell Biol, 2012, 24 (2) :277-283.
  • 2Chiang AC, Massague J. Molecular basis of metastasis[ J]. N Engl Med, 2008, 359(26):2814-2823.
  • 3Huang X, Yuan T, Tschannen M, et al. Characterization of human plasma-derived exosomal RNAs by deep sequencing [ J ]. BMC C, enomics, 2013, 14:319.
  • 4Wu X, McMurray CT. Calmodulin kinase Ⅱ attenuation of gene transcription by preventing cAMP response element-binding protein (CREB) dimerization and binding of the CREB-binding protein [j]. J Biol Chem, 2001, 276(3) :1735-1741.
  • 5Johannessen M, Delghandi MP, Moens U. What turns CREB on [J]? Cell Signal, 2004, 16(11):1211-1227.
  • 6Boer U, Eglins J, Krause D, et al. Enhancement by lithium of cAMP-induced CRE/CREB-directed gene transcription conferred by TORC on the CREB basic leucine zipper domain [ J ]. Biochem J, 2007, 408( 1 ) :69-77.
  • 7Flammer JR, Popova KN, Pflum MK. Cyclic AMP response element-binding protein ( CREB ) and CAAT/enhancer-binding prntein beta (C/EBPbeta) bind ctlimeric DNA sites with high affinlty[J]. Biochemistry, 2006, 45(31 ) :9615-9623.
  • 8Impey S, McCorkle SR, Cha-Molstad H, et al. Defining the CREB regtdon: a genome-wide analysis of transcription factor regulatory regions [ J ]. Cell, 2004, 119 (7) : 1041-1054.
  • 9Kitagawa K, Sasaki T, Terasaki Y, et al. CREB activation is a key player for ischemic tolerance in the brain[ J]. Rinsho Shinkeigaku, 2012, 52( 11 ) :904-907.
  • 10Wang P, Yan H, Li JC. CREB-mediated Bcl-2 expression in trichosanthin-induced HeLa cell apoptosis [ J ]. Biochem Biophys Res Commun, 2007, 363( 1 ) :101-105.

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解剖学报
2012年 第1期

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