摘要
目的:探讨甲状腺乳头状癌雌激素受体阳性表达的临床病理意义。方法:应用免疫组化SP法对80例甲状腺乳头状癌,30例滤泡状癌及50例癌旁正常甲状腺组织雌激素受体(ER)进行测定。结果:甲状腺乳头状癌、滤泡状癌及正常组织ER阳性率分别为67.50%(54/80)、23.33%(7/30)及6%(3/50);乳头状癌ER阳性率显著高于滤泡状癌及正常组织;乳头状癌中原发癌ER阳性率显著高于复发癌,无淋巴结转移者ER阳性率显著高于有淋巴结转移者,女性ER阳性率显著高于男性。结论:甲状腺乳头状癌ER阳性率显著高于滤泡状癌及正常组织甲状腺乳头状癌的发生与雌激素关系密切,检测其ER有助于指导治疗。
Objetive:To study the clinical and pathological significance of estrogen receptor expression in papillary thyroid carcinoma.Methods:Expression of estrogen receptor (ER) were detected by immunohistochemistry SP method in 80 cases of thyroid papillary carcinoma and 30 cases of follicular carcinoma and 50 cases of pericancerous normal thyroid tissue. Results:The positive rate of ER was 67.5%(54/80) in papillary carcinoma, 23.33%(7/30) in follicular carcinoma,and 6%(3/50) in normal thyroid tissue.The results showed that the positive rate in papillary carcinoma was significantly higher than that in follicular carcinoma and normal thyroid tissue.The positive rate in primary papillary carcinoma was significantly higher than that in cases of recurrence,the positive rate in cases without neck lymph node metastasis was significantly higher than that in cases with neck lymph node metastasis,the positive rate in female was significantly higher than that in male.Conclusion:Thyroid papillary carcinoma was associated with estrogen,and detection of ER in thyroid papillary carcinoma was helpful for the treatment.
出处
《四川肿瘤防治》
2000年第1期15-16,共2页
Sichuan Journal of Cancer Control
关键词
甲状腺癌
乳头状癌
雌激素
受体
Thyroid
Papillary carcinoma
Estrogen
Receptor
