摘要
目的 :探讨肝癌CT边缘形态与瘤内微血管密度的关系。方法 :分析 2 1例块状型肝癌的CT边缘特征 ;从手术切除标本上取材行免疫组化微血管染色。结果 :CT上肿瘤边界清楚型微血管密度 (MCD)为 18.3± 11.4,强化率为2 0 .3 %± 10 .3 % ,分别低于肿瘤边界模糊型的MCD( 4 4.1± 19.3 )和强化率 ( 4 6.7%± 13 .7% ) (二者 0 .0 1>P <0 .0 5 ) ;混合型的边缘清楚区的MCD为 2 1.6± 14 .7,而模糊区为 3 9.7± 10 .4( 0 .0 1<P <0 .0 5 )。结论 :CT边界清楚区的MCD较低 ,提示瘤细胞生长较不活跃 ,而CT边界模糊区的MCD较高 ,提示瘤细胞生长活跃。肝癌的CT边缘形态特征 。
Objective: To explore the relationship between the quantity of microvasculature and the marginal features of massive hepatocellular carcinomas(HCCs) on CT scan. Methods: Twenty one patients with HCCs underwent CT scanning. On the plain CT, the marginal features of HCCs were classified into three types: the well circumscribed, the poor circumscribed and the mixed. After surgical resection, fresh tissues were sampled corresponding to the well circumscribed and poor circumscribed borders of HCCs. Then ,the microvessel density count(MDC) were determined under microscope by immunohisto chemical staining for the endothelial marker. Results: MDC from the borders of HCCs with the well circumscribed margin on CT was 8.3±11.4, significantly lower than that from the borders of HCCs with the poor circumscribed margin(44.1±19.3, 0.01> P >0.05). Moreover, the CT contrast enhancing rate from the well circumscribed borders was 22.3%±10.3%, while 46.7%±13.7% from the poor circumscribed boredrs (0.01< P <0.05). Of HCCs with the mixed margin,MDC from its clear borders reached 21.6±14.7, whereas 39.7±10.4 from its hazy borders(0.01< P <0.05). Conclusions: Our results indicate that the tumor tissue from the poor circumscribed border tends to have higher MDC level and higher proliferative activity, whereas the tumor tissue from the well circumscribed border tends to have lower MDC level and lower proliferative activity. The marginal features of HCCs on CT may be significantly related to degree of angiogenesis in HCCs.
出处
《放射学实践》
2000年第1期30-32,共3页
Radiologic Practice
关键词
肝癌
CT
血管生成
Hepatocellulr carcinoma Computed tomography Angiogenesis
