摘要
目的 了解食管癌根治术后胸腔胃不同部位的压力及pH值的变化,评价比较胃肠动力药物对胃压力波的影响,为术后选择用药提供依据。 方法 20例胸中、上段食管癌患者,经右胸作食管癌切除,胃代食管颈部吻合。于术后14～16天随机分为多潘立酮组和西沙必利组,每组10例,于口服相同剂量(20mg)多潘立酮或西沙必利前、后分别描记胸腔胃压力波,测量其频率、峰值和峰值持续时间,比较服药前、后的变化。同时逐段测定胸腔胃基础pH值。结果 两组胸腔胃基础压力值无差异。多潘立酮对胸腔胃的压力峰值有正性作用,但以胃窦区为显著(P<0.01),西沙必利则明显增高胸腔胃各段的压力峰值;胃内自下而上pH值渐次升高,较正常酸度降低。 结论 食管癌术后胸腔胃呈一相对高频低幅的压力变化,胃内酸度降低。多潘立酮和西沙必利均有一定增高胸腔胃压力幅度的效果。
Objective To investigate the change of pressure wave and pH in thoracic stomach after the operation of esophageal carcinoma, and compare the effect of two stomach and intestines kinetic drugs on thoracic stomach. Methods Twenty patients diagnosed esophageal carcinoma were enrolled in this study. The patients were radomizely divided into two groups:Domperidoni group ( n =10) and Cisapridi group ( n =10).After two weeks of operation, the pressure in different segment of stomach was detected before and after oral Domperidoni or Cisapridi. Meantimes, the basic pH of stomach was tested. Then, to compare the pressure wave index, including the frequency, peak value and floor stage. Results There was no significance on stomach base pressure wave in two groups. The Domperidoni had some effect on increasing the stomach peak value, but only on inferior segment. The Cisapridi could promote the peak value obviously on each segment of thoracic stomach ( P <0 01). The stomach pH increased slightly (mean pH=3 4). Conclusion The pressure wave of thoracic stomach appeared a relative high frequency and low peak value situation and the pH ascended slightly. Domperidoni and Cisapridi had some effect on increasing the peak value of postoperative thoracic stomach. Cisapridi was more effective than that of Domperidoni.
出处
《中国胸心血管外科临床杂志》
2000年第1期18-20,共3页
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
关键词
胸腔胃状态
胃肠动力剂
压力波
食管癌
Thoracic stomach Stomach and intestines kinetic drug Pressure wave
