摘要
慢性阻塞性肺疾病（COPD）近年来发病率和病死率呈上升趋势，目前对其发病机制尚未完全明确，其发病机制的探索显得格外重要。转化生长因子目（transforming growth factorp β1，TGF-β1）是一个多功能的细胞因子，近年来格外受到关注。研究表明，TGF-β1与COPD发生发展有着重要的联系，现在就TGF-β1的结构、生理功能、吸烟、基因多态性、肺功能及其与COPD相关性的研究进展进行概述。
The morbidity and mortality of chronic obstructive pulmonary disease （COPD） is rising in recent years, which pathogenesis is not so clearly that the research on it is more and more important. Transforming growth factor β1 （TGF-β1） is a multifunctional cytokine and received a wide publicity. Studies demonstrated that TGF-β1 has a critical association with development of COPD. The view summarizes its structure, biological function, smoking, gene polymorphism, lung function and its relationship of COPD.
出处
《国际呼吸杂志》
2012年第3期215-218,共4页
International Journal of Respiration
关键词
慢性阻塞性肺疾病
转化生长因子Β1
基因多态性
Chronic obstructive pulmonary disease
Transforming growth factor β1 Gene polymorphism
