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乙酰肝素酶与糖尿病性肾病的相关性研究进展

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摘要 糖尿病性肾病（diabetic nephropathy,DN）是糖尿病患者的重要死因,同时又是导致肾功能衰竭的一个重要疾病。早期诊断DN,有利于提高糖尿病患者的生存率、生活质量,减少国家的医疗负担。目前尚缺乏更优于尿微量白蛋白的检测指标,
作者 熊琪辉 甘华侠
机构地区 南昌大学研究生院医学部 南昌大学第一附属医院内分泌科
出处 《实用临床医学（江西）》 CAS 2011年第10期137-139,共3页 Practical Clinical Medicine
关键词 乙酰肝素酶 糖尿病性肾病 蛋白尿 综述
分类号 R587.2 [医药卫生—内分泌]
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参考文献23

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二级参考文献7

  • 1Conde-Knape K. Heparan sulfate proteoglycans in experimental models of diabetes: a role for perlecan in diabetes complications. Diabetes Metab Res Rev, 2001, 17: 412-421.
  • 2Vlodavsky I, Friedmann Y, Elkin M, et al. Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis. Nat Med, 1999, 5: 793-802.
  • 3Jeansson M, Haraldsson B. Glomerular size and charge selectivity in the mouse after exposure to glycosaminoglycandegrading enzymes. J Am Soc Nephrol, 2003, 14: 1756- 1765.
  • 4Maxhimer JB, Somenek M, Rao G, et al. Heparanase-1 gene expression and regulation by high glucose in renal epithelial cells: a potential role in the pathogenesis of proteinuria in diabetic patients. Diabetes, 2005, 54: 2172- 2178
  • 5van den Hoven MJ, Rops AL, Bakker MA, et al. Increased expression of heparanase in overt diabetic: nephropathy. Kidney Int, 2006, 70: 2100-2108.
  • 6Wijnhoven TJ, den Hoven M J, Ding H, et al. Heparanase induces a difterential loss of heparan sulphate domains in overt diabetic nephropathy. Diabetologia, 2008, 51: 372-382.
  • 7唐琳,王玉华,刘章锁,肖静,窦艳娜,董吉.乙酰肝素酶在糖尿病肾病大鼠蛋白尿发生中的作用[J].中华肾脏病杂志,2008,24(4):277-281. 被引量：4

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实用临床医学（江西）
2011年 第10期

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