摘要
目的 观察硫喷妥钠、咪唑安定、依托咪酯以及异丙酚麻醉诱导对琥珀胆碱引起的血钾升高、肌颤和肌痛的影响。方法 ASAⅠ～Ⅱ级病人 6 0例 ,随机分为四组 ,分别采用硫喷妥钠、咪唑安定、依托咪酯或异丙酚静脉诱导 ,静注琥珀胆碱后行气管插管。于诱导前、气管插管前和插管后测定血清钾浓度 ,并观察诱导期病人肌颤及术后病人肌痛的发生率。结果 各组病人诱导前及气管插管前的血钾浓度组间及组内比较均无明显差异 (P >0 .0 5 ) ,与诱导前相比 ,插管后硫喷妥钠组和依托咪酯组的血钾浓度分别升高 3.4%和 5 .3% (P <0 .0 1) ,咪唑安定组和异丙酚组的血钾浓度则无明显改变 (P >0 .0 5 )。异丙酚组和咪唑安定组肌颤和肌痛的发生率明显低于依托咪酯组和硫喷妥钠组 (P<0 .0 5 )。结论 咪唑安定和异丙酚能有效地防止琥珀胆碱引起的血钾浓度升高、肌颤和肌痛 ,而硫喷妥钠和依托咪酯则不能。
Objective To investigate the influence of thiopentone, midazolam, etomidate and propofol on the suxamethonium-induced serum potassium increase, muscle fasciculations and myalgia Methods Sixty patients, ASA class Ⅰ-Ⅱ were allocated randomly to receiving intravenous thiopentone 5mg/kg(thiopentone-group), midazolam 0.3mg/kg( midazolam-group), etomidate 0.3mg/kg(etomidate-group)or propofol 2mg/kg(propofol-group) respectively, followed by intravenous suxamethonium and tracheal intubation. Serum potassium concentration was measured before induction and intubation and after intubation. The incidences of muscle fasciculation during induction and postoperative mylgia were observed .Results As compared with that before induction ,the serum potassium levels in thiopentone- and etomidate-group increased significantly by 3.4% and 5.3% respectively after induction (P<0.01), but did not significantly change in midazolam- and propofol-group(P>0.05).The incidences of muscle fasciculation and postoperative myalgia inmidazolam- and propofol -group were significantly lower than in thiopentone- and etomidate -group (P<0.01 or P<0.05)。Conclusions Midazolam and propofol effectively reduce the suxamethonium-induced serum potassium increase, muscle fasciculations and myalgia , but thiopentone and etomidate do not.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2000年第1期11-13,共3页
Chinese Journal of Anesthesiology
关键词
麻醉诱导药
血钾浓度
肌颤
肌痛
serum potassium
fasciculation
myalgia
Thiopentone
Midazolam
Etomidate
Propofol
