摘要
目的：探讨内毒素型肺损伤与一氧化氮的关系及山莨菪碱对其影响。方法：３０只ＳＤ大鼠随机分成对照组、ＥＴ组、ＥＴ＋山莨菪碱组，静脉注射内毒素（２００ug/kg）造成急性 肺损伤。结果：４h后血浆和肺组织匀浆中ＮＯ２/ＮＯ３含量和丙二醛（ＭＤＡ）含量、肺系数、肺含水量、肺干湿相对密度均显著升高，与对照组比较差异有显著性（Ｐ＜０．０５或Ｐ＜０．０１），人毒素后５min。
Objective:studies on alternations of the production of nitric oxide and endotoxin-induced lung injury and the benefical effect of anisodamine.Methods:30 rats were divided randomly into three groups:control (n=10),ET (n=10) and ET+anisodamine (n=10).Acute lung injury was induced by a single intravenous injection of endotoxin at the dosage of 200 μg/kg body weight.Results:Four hours after endotoxin injuction.The malondialdehyde (MDA) content and NO - 2/NO - 3 content in plasma and lung homogenate,the ratio of wet lung-to body weight,lung index and water content were increased significantly as compared with the control values.Treatment with anisodumine(5 mg/kg iv given 5min,2h after administration of endotoxin) markedly attenuated the endotoxin-induced lung injury as well as the increase in MDA content and NO - 2/NO - 3 content.A close correlation was shown beween MDA content and NO - 2/NO - 3 content in lung homogenate.Conclusion:These results suggested that lipoperoxidation and nitric oxide release may be involved in the pathogenesis of acute lung injury caused by endotoxin.Anisodamine inhibits endotoxin induced NO release and lipoperoxidation.
出处
《医师进修杂志》
2000年第1期20-22,共3页
Journal of Postgraduates of Medicine
关键词
内毒素
肺损伤
一氧化氮
山莨菪碱
丙二醛
anisodamine
lung injury
endotoxin
nitric oxide
malondiadehyde
