摘要
目的：探讨硫酸镁治疗哮喘的疗效。方法：将５０例急性发作期重度哮喘患者分为两组。对照组２０例，先予以５％葡萄糖２０ml＋喘定０．２５g每日１次静注，继之５％葡萄糖５ ００ml＋喘定０．５g＋地塞米松５mg每日１次静滴（滴速３０滴/分），博利康尼２．５mg每日３次口服，并辅以一般治疗。治疗组３０例，除应用上述治疗外，仅在静滴的那组液体中加入２５％硫酸镁１０ml。１周为１个疗程，随时观察患者的临床表现。
Objective:To study the efficacy of intravenous magnesium sulfate (MgSO 4) in the treatment of bronchial asthma.Method:50 patients with severely acute attack bronchial asthma were divided into two groups randomly.(1)Control group (20 cases),First they were administered 5% glucose 20ml plus glyphylline 0.25 intravenously once a day,and then intravenous 5% glucose 500ml plus glyphylline 0.5g plus dexamethasone 5mg once a day (30 drops/minute),bricanyl 2.5mg oral three times a day.All patients received the treatment of inhaling oxygen,resisting infection and removing sputum.(2)Treated group (30 cases):They received 25% MgSO 4 10ml intravenously,in addition to above treatment,one week as a course of treatment.The patients's clinical findings were observed at all times.Peak expirtory flow (PEF) was measured before and after intravenous every day.The treatments were considered effective when PEF after treatment increased 15% than primory PEF without treatment,observing the efficacy and the time which reached effective of the two grous.Result:In control group,there are 3 cases reached effect at 36～72 hours during administering (improved 3 cases),14 cases reached effect over 72 hours during administer(obviously improved 6 cases,improved 8 cases) effective rate 85%(17/20);invalid 3 cases,In treated group,there are 29 cases reached effect at 12～70 hours during administering (obviously improved 18 cases,improved 11 cases),1case reached effect at 75 hours (improved 1 case),effective rate 100%(30/30).The effective rate of treated group was significant higher than control group (P<0.05),.Conclusion:Use MgSO 4 on the basis of routine treatment,we can increased the efficacy and shortened the time of reach effect in the treatment of bronchial asthma.
出处
《医师进修杂志》
2000年第1期25-27,共3页
Journal of Postgraduates of Medicine
