期刊文献+

HCV核酸疫苗研究进展

暂未订购
导出
摘要 丙型肝炎病毒是目前输血后肝炎的主要病因。并且与肝硬化和肝癌的发生和发展密切相关。由于HCV存在不同的基因型,基因突变率高,特别是HCV相似株的存在和免疫逃避现象,使传统疫苗的研制存在一定困难。随着基因免疫和基因治疗的兴起,HCV核酸疫苗的研制就成为许多研...
出处 《四川医学》 CAS 2000年第2期147-148,共2页 Sichuan Medical Journal
  • 相关文献

参考文献9

  • 1Valeria Tedeschi,et al.A specific antibody response to HCV E2 elicited in mice by intramuscular inoculaion of plasmid DNA containing coding sequences for E2.Hepastology,1997,25(2):459
  • 2Lagging LM,et al.Immune response to plasmid DNA encoding the hepatitis C virus core protein.J Virol,1995,69(9):5869
  • 3Tokushige K,et al.Expression and immune response to hepatitis C virus core DNA based vaccine construct.Hepatology,1996,24 (1):14
  • 4Major ME,et al.DNA-based immunization with chimeric vectors for the induction of immune response against the hepatitis C virus necleocapsid.J Virol,1995,69(9):2798
  • 5Geissler M,et al.Differential cellur and hurnoral immune response to HCV core and HBV envelope proteins after genetic immunization using chimeric contructs.Vaccine,1998,16 (8):857
  • 6Nakano I,et al.immunization with plasmid DNA encoding hepatitis C virus envelope E2 antigenic domains induce antibodies whose immune reactivity is linked to the injection mode.J Virol,1997,71 (9):7101
  • 7King CA,et al.DNA vaccines with single-chain Fv fused to fragment C of tetanus toxin induce protective immunity against lymphoma and myeloma.Nature Med,1996(2):1038
  • 8Lee SW,et al.optimal induction of hepatitis C virus enelope-specific immunity by bicistronic plasmid DNA inocultion with the granulocytemacrophage colony-stimulating factor gene.J Virol,1998,72 (10):8430
  • 9Zibart A E,et al.Antibodies in human sera specific to hypervariable region 1 of hepatitis C virus can block viral attachment.Virology,1995,208:653

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部