摘要
目的 探讨体重指数（BMI）及多囊卵巢综合征（PCOS）对体外受精（IVF）-胚胎移植周期（ET）治疗结局的影响.方法 回顾性分析483个（例）激动剂长方案IVF周期,其中PCOS因素周期153例,单纯输卵管因素周期275例.两组患者再分别根据BMI分为超重组（BMI≥24）和正常体重组（BMI＜24）.比较各组促性腺激素用量、用药天数、获卵数、卵子成熟率、受精率、优质胚胎数、种植率、临床妊娠率和早期流产率.结果 PCOS组高BMI患者比例显著高于输卵管因素组（P＜0.01）.PCOS组中,高BMI患者促性腺激素用量及天数显著高于正常BMI患者（P＜0.01）.正常体重的PCOS患者获卵数与优胚数均显著高于其他各组（P＜0.01）.卵子成熟率、受精率、胚胎种植率、临床妊娠率和妊娠早期流产率在各组间均无统计学差异（均P ＞0.05）.结论 肥胖合并PCOS时降低卵巢对促性腺激素反应.非肥胖型PCOS利于促排卵.肥胖及PCOS均未影响IVF妊娠结局.
Objective To investigate the effect of body mass index （BMI） and polycystic ovarian syndrome （PCOS） on the outcome of in vitro fertilization-embryo transfer （IVF-ET）. Methods A retrospective analysis was performed on 153 infertility patients with PCOS and 275 patients with tubal factors who underwent agonist long-protocol IVF-ET. Patients were then divided into overweight （BMI ≥ 24） or normal weight （BMI 〈24） groups. Parameters including the dose of gonadotropins, the duration of stimulation, number of retrieved oocytes, maturation rate, fertilization rate, the number of high-quality embryos, implantation rate, clinical pregnancy rate and first-trimester abortion rate were compared between groups. Results The percentage of over weight patient was significantly higher in PCOS group （P〈0.01）. The dose of gonadotropins was higher and the duration of stimulation was longer in over weight patients than those of normal weight in PCOS group（ P〈0.01 ）. Significantly more retrieved oocytes and high-quality embryos were observed in normal weight PCOS group （P〈0.01）. The differences of the maturation rate, fertilization rate, implantation rate, pregnancy rate and abortion rate were not significant among these groups （P 〉0.05）. Conclusion PCOS with high BMI has a negative effect on the ovarian response to gonadotropins. The presence of PCOS in non-obese patient is a fa- vorable prognostic factor in ovarian stimulation. Both PCOS and BMI have no effect on the pregnancy outcome of IVF.
出处
《浙江医学》
CAS
2011年第12期1750-1752,共3页
Zhejiang Medical Journal
关键词
多囊卵巢综合征
体重指数
体外受精-胚胎移植
促排卵
Polycystic ovarian syndrome BMI In vitro fertilization-embryo transfer Ovarian stimulation
