摘要
利用精密挤出沉积自由成形技术制备骨组织工程用羟基磷灰石多孔生物支架,探讨工艺参数对支架孔洞成形的影响,评价支架的力学性能并分析影响强度的微观因素.结果表明:通过调整工艺参数,采用挤出沉积工艺可制备出具有可控结构、良好连通性的生物支架;支架具有良好的力学性能,经过微波烧结处理后,孔隙率为56.2%的支架平均抗压强度为45.2MPa,致密化程度与晶粒尺寸是影响支架强度的主要微观因素.同时,该结构的支架能够为细胞的分化与新生组织的生长提供持续的强度支持,满足组织工程支架结构与力学性能要求.
Hydroxyapatite porous scaffolds were fabricated for bone tissue engineering by using motor assisted micro-syringe precision extrusion deposition freeform fabrication system.The key process parameters that influence the formation of pores were analyzed.Mechanical property of scaffolds and its influence factors were also studied.By adjusting process parameters,porous scaffolds were fabricated with controlled structure and high connectivity.The scaffolds gained high strength after microwave sintering.The average compressive strength was 45.2 MPa under porosity of 56.2%.Densification and grain size were the main micro factors that affect the strength.Meanwhile,the scaffolds could provide continuous strength to support cell differentiation and tissue growth in the degradation process.The results show that the scaffolds fabricated meet the structural and mechanical requirements for bone tissue engineering.
出处
《华中科技大学学报（自然科学版）》
EI
CAS
CSCD
北大核心
2011年第12期33-36,共4页
Journal of Huazhong University of Science and Technology(Natural Science Edition)
基金
中央高校基本科研业务费资助项目(J2009012)
关键词
挤出沉积成形
羟基磷灰石
组织工程
支架
可控结构
precision extrusion deposition
hydroxyapatite
tissue engineering
scaffold
controlled structure
