摘要
目的:探讨临床应用米索前列醇预防产后出血的效果。方法:选取我科2009年7月～2010年12月间住院并经阴道正常分娩的产妇400例,随机分为米索组132例、米索+缩宫素组142例及缩宫素组126例,三组患者临床资料比较无明显统计学差异。3组给药时间均为胎儿娩出后,米索组胎儿娩出后立即口服米索前列醇400μg;米索+缩宫素组胎儿娩出后立即静脉滴注缩宫素20U并口服米索前列醇400μg,缩宫素组胎儿娩出后立即静脉滴注缩宫素20U。临床观察3组分娩后2h内阴道出血量。结果:观察3组患者产后2h内阴道平均出血量,米索组为(280±46)mL;米索+缩宫素组为(216±45)mL;缩宫素组为(360±49)mL;组间比较差异显著,以米索+缩宫素组最优,米索组次之,缩宫素产后出血发生率最高。比较差异具有统计学意义(P<0.01)。结论:米索前列醇可促进子宫收缩,作用强于缩宫素,能较好的预防产后出血,且用药方便、安全,值得临床推广应用。
Objective： To investigate the clinical effects of misoprostol for preventing postpartum hemorrhage.Methods：In this study,A total of 400 puerpera scheduled for vaginal delivery in the Department of Obstetrics of our hospital during July 2009 and December 2010 were enrolled and randomly divided into 3 groups.Treatments were all given immediately after the fetus was delivered.For the misoprostol group,oral administration of 400μg misoprostol;for oxytocin ＋ misoprostol group,oral administration of 400μg misoprostol ＋ intravenous drip of 20U oxytocin was given,while the oxytocin group was only given intravenous drip of 20U oxytocin.Average amount of bleeding 2 h post-partum of the three groups were observed and compared.Results：Average amount of bleeding 2 h post-partum of the three groups were listed as following： misoprostol group,（280±46）mL;oxytocin ＋ misoprostol group,（216±45）mL;oxytocin group,（360±49）mL;indicating significant better prevention effects in oxytocin ＋ misoprostol group comparing with that in other two groups.Oxytocin group showed the highest incidence of post-partum bleeding（P0.01）.Conclusions：Misoprostol can promote stronger uterine contractions than oxytocin,thus has good prevention effects for post-partum bleeding.
出处
《海南医学院学报》
CAS
2012年第1期139-141,144,共4页
Journal of Hainan Medical University
基金
海南医学院科研基金资助学报项目(0020120042)~~
关键词
米索前列醇
产后出血
预防
Misoprostol
Postpartum hemorrhage
Prevention
