摘要
目的评价伏立康唑治疗ICU侵袭性真菌感染的有效性与安全性。方法收集我院2010年1月～2011年10月的ICU侵袭性真菌感染患者40例,均给予伏立康唑,观察症状体征、实验室及细菌学指标,并对该药疗效与副作用进行描述与评价。结果在本组40例患者中,痊愈6例,显效27例,进步4例,无效3例,总有效率82.5%;40例患者中9例发生伏立康唑相关不良反应事件,不良事件发生率22.5%,经治疗后均能好转。结论伏立康唑治疗ICU侵袭性真菌感染具有广谱抗真菌功效,同时它所引发的不良事件较少且多能耐受。
Objective To evaluate the efficacy and security of voriconazole injection in the treatment of patients with invasive fungal infections. Methods Chosed 40 ICU patients with invasive fungal infections treated in our hospital from January 2010 to October 2011. All cases received the voriconazole injection. Observed the symptoms, signs ,laboratorial indices and bacteriological indices, and described and evaluated the effect and side effects. Results 6 of 40 cases in this study recovered, 27 had the significant effect, 4 had the progress and 3 had no effect,with the total effective rate of 82.5%; 9 of 40 cases had the voriconazole-related adverse reactions,with the rate of adverse reactions of 22.5% ,who all became better after the treatment. Conclusion The voriconazole has the broad-spectrum antimierobial effect in the treatment of ICU patients with invasive fungal infections, while it causes little and acceptable adverse reactions.
出处
《中国现代医生》
2012年第2期159-160,共2页
China Modern Doctor
