摘要
目的:探讨心脏移植术3个月后,影响患者环孢素A(CsA)血药浓度的因素。方法:某医院先后采用双腔静脉法进行了10例同种异体心脏移植,术后均采用CsA口服联合免疫抑制治疗。采用多元线性回归回顾性分析同一患者在不同时期的CsA剂量、膳食结构、体重变化、肝功能、合用影响CsA代谢的药物对CsA血药浓度的影响。结果:同一患者在不同时期内CsA剂量、患者饮食结构和合用药物对CsA血药浓度的影响较大。结论:心脏移植患者术后应讲究平衡饮食,不要随便更改饮食结构。合用其他药物应咨询心脏或免疫科医生并检测CsA浓度。
Objective： To find the influential factor to the blood concentrations of ciclosporin A（CsA） in patients with heart transplantation.Methods： Ten patients underwent heart transplantation and immune suppression by sandimmun neural,mycophenolate mofetil and prednisone.The selected factors are dosage of CsA,dietary pattern,change of body weight,hepatic function,administration by other drugs,self-feeling healthy score,and to find out the influential factor on the blood concentration of CsA by multiple linear regression analysis.Results： Dosage of CsA,dietary pattern,self-feeling healthy score and administration by the drugs impacted the bioavailability of CsA are the risk factors disturbed the blood concentrations of CsA.Conclusion： The balanced diet is important to immunotherapy by CsA on patients with heart transplantation.Moreover,we should suggest patients to consult heart and immunologic doctors before administration by other drugs.
出处
《安徽卫生职业技术学院学报》
2011年第6期60-61,共2页
Journal of Anhui Health Vocational & Technical College
关键词
心脏移植
CSA
血药浓度
回归分析
heart transplantation
ciclosporin A
blood concentrations
regression analysis
