摘要
目的:探讨p38MAPK在大鼠胃缺血再灌注损失中的作用。方法:30只SD大鼠随机分为假手术组和胃缺血再灌注损伤组,分别在胃缺血再灌注损伤的0、0.5、1、3、6、12 h处死大鼠,切除胃组织标本做病理检查;用免疫组化方法检查p38MAPK在胃组织中的表达。结果:p38MAPK在胃缺血再灌注损伤中表达增强;胃缺血再灌注损伤后0.5 h表达即明显增加,1 h达高峰,再灌注3 h有所下降,而后又上升并维持在相对较高水平再灌注12 h。结论:p38MAPK缺血再灌注损伤的发展过程中发挥着不同程度的作用。
Objective：To study the role of p38MAPK in rat stomach ischemia-reperfusion injury.Methods：30 SD rats were randomly divided into control group and stomach ischemia-reperfusion injury group.Rats were executed to death at 0,0.5,1,3,6,12 h after stomach ischemia-reperfusion injury and the stomach specimens were taken for pathologic examination.The expression of p38MAPK was detected by the immunohistochemical method.Results：The expression of p38MAPK in the stomach ischemia reperfusion injury was increased,which was significantly increased after 0.5h of stomach ischemia-reperfusion injury,reached the high peak till 1 h,declined till reperfusion 3 h,and then again rose and maintained at relatively high level till reperfusion 12 h.Conclusion：p38MAPK play an important role in the process of stomachs ischemia-reperfusion injury.
出处
《现代医药卫生》
2011年第24期3681-3682,F0003,共3页
Journal of Modern Medicine & Health
