期刊文献+

Gilbert综合征——肝移植术后胆红素升高的罕见原因 被引量:2

Gilbert Syndrome—A Rare Etiology to Elevated Bilirubin after Liver Transplantation
暂未订购
导出
摘要 Gilbert综合征是肝移植术后中、远期高胆红素血症一个罕见的病因。目前,在我国肝移植领域还缺乏对本病的清楚认识,当移植受者罹患本病时,往往得不到正确的诊治及合理的解释,造成患者心理及经济上的负担。本文详细阐述了本病的定义、发病机理、临床表现、诊断方法及预后,旨在提高广大业内人士对本病的认识。 Gilbert syndrome is a rare etiology of elevated bilirubin in mid--later stage after liver transplantation. At presently, the syndrome had not been recognized in liver transplantation field in our country. When a recipient suffered from the syndrome, the patient often was hard to be given correcting diagnosis and reasonable explain. It would bring about the burden on patient's psychology and economy. The article expounded definition, mechanism, clinic situation, diagnosis and prognosis about the syndrome in detail. Our purpose is to elevate understanding about the disease in liver transplantation field.
出处 《医学与哲学(B)》 2011年第12期51-52,共2页 Medicine & Philosophy(B)
关键词 肝移植 非结合胆红素 GILBERT综合征 liver transplantation, unconjugated bilirubin, Gilbert syndrome
  • 相关文献

参考文献2

二级参考文献18

  • 1Henne-Bruns D, Kremer B. Manifestation of Gilbert syndrome (Meulengracht disease) following orthotopic liver transplantation: a rare cause of postoperative hyperbilirubinemia. Klin Wochenschr, 1988, 66(13) :596 598.
  • 2Gates LK Jr, Wiesner RH, Krom RA, et al. Etiology and incidence of unconjugated hyperbilirubinemia after orthotopic liver transplantation. Am J Gastroenterol, 1994, 89(9):1541-1543.
  • 3Clarke DJ, Moghrabi N, Monaghan G, et al. Genetic defects of the UDPglucuronosyhransferasc-1 (UGT1) gene thai cause familial non haemolytic uneonjugated hyperbilirubinaemias. Clin Chim Acta, 1997, 266(1) :63- 74.
  • 4Te HS, Schiano TD, Das S, et al. Donor liver uridine diphosphate ( UDP)-glueuronosyltransferase-1A1 deficiency causing Gilbert's syndrome in liver transplant recipients. Transplantation, 2000, 69(9) : 1882-1886.
  • 5Lachaux A, Aboufadel A, Chambon M, et al. Gilbert's syndrome: a possible cause of hyperbilirubinemia after ortholopic liver transplontation. Transplant Proc,1996, 28(5) :2846.
  • 6Jansen PL, Bosma PJ, Bakker C, et al. Persistent unconjugated hyperbilirubinemia after liver transplantation due to an abnormal bilirubin UDP-glucuronosyltransferase gene promoter sequence in the donor. J Hepatol, 1997, 27(1):1-5.
  • 7Gilbert A, Lereboullet P. La cholemie simple familiale. Semaine Medicele, 1901, 21 : 241-243.
  • 8Clarke D J, Moghrabi N, Monaghan G, Cassidy A, Boxer M,Hume R, Burchell B. Genetic defects of the UDP glucuronosyltransferase-1 ( UGT1 ) gene that cause familial nonhaemolytic unconjugated hyperbilirubinaemias. Olin Ohim Acta, 1997, 266(1): 63-74.
  • 9Bosma P J, Ohowdhury d R, Bakker C, Gantla S, de Boer A,Oostra B A, lindhout D, Tytgat G N, Jansen P L, Oude Elferink R P, et al. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltrasferase 1 in Gilberts syndrome. N Engl J Med, 1995, 333(18): 1171-1175.
  • 10Sampoetro M, Iolascon A. Molecular pathology of Crigler-Najjar type Ⅰand Ⅱ and Gilbert's syndromes. Haematologica,1999, 84(2): 150-157.

共引文献15

同被引文献30

引证文献2

二级引证文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部