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RUNX3蛋白与Bcl-2家族蛋白在结肠癌中的表达及其意义 被引量：1

The Expression of RUNX3 Protein and Bcl-2 Family Protein in Colon Cancer and its Clinical Signifi-cance
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摘要 [目的]探讨RUNX3蛋白与Bcl-2家族蛋白在结肠癌中的表达及与患者生存率的关系。[方法]采用免疫组化染色检测RUNX3、Bim、Bax与Bcl-2在98例结肠癌组织及癌旁正常组织中的表达情况。[结果]RUNX3在结肠癌原发灶中的表达显著低于癌旁正常组织(25.5%vs89.8%)。Bim在正常组织中阳性表达率为98.9%,而在癌组织中表达率为28.6%(P<0.001);Bax蛋白在正常组织阳性表达率为98.9%,癌组织中阳性表达率为23.5%(P<0.001);Bcl-2蛋白在正常组织中阳性表达率为25.5%,癌组织中阳性表达率80.0%(P<0.001)。Kaplan-Meier分析显示RUNX3在细胞核中阳性表达组生存时间均高于阴性表达组(P<0.001)。[结论]Bcl-2家族蛋白协同RUNX3蛋白,在结肠癌发生、进展中起重要作用。
作者 叶盛前 叶菲 金银姬 王天真 吴旖琦 刘端阳 佟丹丹 张磊 金晓明
机构地区 哈尔滨医科大学病理学教研室
出处 《肿瘤学杂志》 CAS 2011年第12期893-896,共4页 Journal of Chinese Oncology
基金 哈尔滨市科技创新人才研究专项资金(RC2009QN004149) 黑龙江省卫生厅科研课题(2009-209) 黑龙江省青年科学基金(QC2009C29)
关键词 结肠肿瘤 RUNX3 BCL-2家族 生存率 免疫组织化学
分类号 R735.3 [医药卫生—肿瘤]
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参考文献17

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二级参考文献7

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共引文献4

同被引文献27

  • 1王珣,王明林,胡义奎.RUNX3蛋白在人结直肠癌中的表达及其临床意义[J].胃肠病学,2007,12(7):414-416. 被引量：6
  • 2Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009. CA-Cancer J Clin, 2009, 59(4): 225-249.
  • 3Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA-Cancer J Clin, 2011, 61(2): 69-90.
  • 4Lee Y M. Control of RUNX3 by histone methyltransferases. J Cell Biochem, 2011, 112(2): 394-400.
  • 5Bosman F T, Cameiro F, Hruban R H, et al. World health organization classification of tumours of the digestive system. Lyon: IARC Press, 2010.
  • 6Wells GA, Shea B, O’connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 3rd Symposium on Systematic Reviews: Beyond the Basics. 2000.
  • 7Bangsow C, Rubins N, Glusman G, et al. The RUNX3 gene–sequence, structure and regulated expression. Gene, 2001, 279(2): 221-232.
  • 8Wei D, Gong W, Oh SC, et al. Loss of RUNX3 expression significantly affects the clinical outcome of gastric cancer patients and its restoration causes drastic suppression of tumor growth and metastasis. Cancer Research, 2005, 65(11): 4809-4816.
  • 9Hiramatsu T, Osaki M, Ito Y, et al. Expression of RUNX3 protein in human esophageal mucosa and squamous cell carcinoma. Pathobiology, 2006, 72(6): 316-324.
  • 10Shima K, Morikawa T, Baba Y, et al. MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers. Cancer Causes & Control, 2011, 22(2): 301-309.

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肿瘤学杂志
2011年 第12期

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