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自然流产的遗传学检测及相关病因学研究 被引量：10

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摘要 目的探讨自然流产病因及FISH技术的临床应用价值。方法对609例自然流产绒毛,应用荧光原位杂交(fluorescence in situ hybridization,FISH)技术,选用13、16、18、21、22和X、Y染色体特异性DNA探针进行检测,同时对这609例绒毛进行常规染色体核型分析。结果 FISH检测结果与染色体核型分析结果一致,609例中,异常267例,异常率为43.84%,其中非整倍体异常243例,占91.01%。结论 1.胚胎染色体数目异常是自然流产的主要原因,FISH技术能快速准确的检测自然流产绒毛染色体的异常。2.绒毛染色体数目异常发生率与孕妇年龄相关,高龄孕妇较非高龄孕妇更易发生。
作者 孙庆云 周丽颖 兰永连 王树玉
机构地区 首都医科大学附属北京妇产医院生殖医学科
出处 《中国优生与遗传杂志》 2011年第12期36-37,共2页 Chinese Journal of Birth Health & Heredity
关键词 染色体数目异常 绒毛 FISH 染色体核型分析 自然流产
分类号 R714.21 [医药卫生—妇产科学]
  • 相关文献

参考文献8

  • 1雷琼,王琼,周灿权,陈宝江,陈争,徐艳文,曾艳红.不同分子遗传学方法用于自然流产绒毛细胞遗传分析的效果[J].中华妇产科杂志,2009,44(4):253-256. 被引量：21
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二级参考文献13

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共引文献20

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二级引证文献112

中国优生与遗传杂志
2011年 第12期

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