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多发性骨髓瘤血管新生研究进展 被引量：3

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摘要 多发性骨髓瘤（MM）骨髓血管再生程度与骨髓瘤细胞的增殖活性高度相关，活动期MM有高水平的血管生成因子。血管新生是肿瘤生长的关键因素。肿瘤血管新生对肿瘤的发生、发展及转移起重要作用。血管新生为MM细胞的生长创造了有利的微环境。靶向血管新生药物的出现，对克服传统药物的耐药和提高MM患者的生存率有重要作用。现就MM血管新生研究进展进行综述。
作者 耿传营(综述) 陈文明(审校)
机构地区 首都医科大学附属北京朝阳医院血液科
出处 《国际输血及血液学杂志》 CAS 2012年第1期25-27,共3页 International Journal of Blood Transfusion and Hematology
关键词 多发性骨髓瘤 血管新生 靶向治疗
分类号 R394.8 [医药卫生—医学遗传学]
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参考文献21

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同被引文献29

  • 1蹇朝,肖颖彬.MIF在心血管疾病中作用的研究现状[J].国际心血管病杂志,2008,35(6):373-376. 被引量：1
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  • 3Cohen KS. Angiogenesis and multiple myeloma:is therea role for angiogenic biomarkers in the context of autol-ogous stem cell transplant Leuk[J], Lymphoma,2011,52(7) :1 173-1 175.
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  • 6Stachel D,Albert M,Meilbeck R,et al. Expression ofan-giogenic factors in childhood B-cell precursor acutelymphoblastic leukemia [J], Oncol Rep, 2007 ,17 ( 1 ):147-152.
  • 7Alexandrakis MG, Sfiridaki A,Miyakis S,et al. Rela-tionship between serum levels of vascular endothelialgrowth factor,hepatocyte growth factor and matrixmetalloproteinase-9 with biochemical markers of bonedisease in multiple myeloma[J]. Clin Chim Acta,2007,379(l-2):31-35.
  • 8Zhang J , Sattler M,Tonon G,et al. Targeting angiogen-esis viaa c-Myc/hypoxia-inducible factor-1 alpha-de-pendent pathway in multiple myeloma[J]. Cancer Res,2009,69(12)-5 082-5 090.
  • 9胡可可,陈晓琼,邓赫男,张琴.巨噬细胞移动抑制因子和血管内皮生长因子在宫颈癌中的表达及意义[J].现代医药卫生,2010,26(7):970-971. 被引量：5
  • 10李治国,曹妍,何丽.多发性骨髓瘤中PTEN蛋白及血管新生调控因子的表达及意义[J].临床检验杂志,2010,28(4):296-297. 被引量：6

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国际输血及血液学杂志
2012年 第1期

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