摘要
目的:分析我院抗菌药物的应用情况及细菌分离和耐药性的变迁特点。方法:调取我院2008-2010年抗菌药物的出库数据,采用金额排序法、用药频度排序法对抗菌药物的使用情况进行统计、分析。结果:3年中,我院抗菌药物使用总金额逐年增长;同期临床分离的常见病原菌以革兰阴性杆菌为主;3年均检出耐万古霉素的粪肠球菌菌株,但尚未见对万古霉素耐药的葡萄球菌菌株出现;革兰阴性杆菌对抗菌药物的耐药率整体呈上升趋势。结论:我院细菌的耐药率与抗菌药物的用药频度呈正相关,临床分离的革兰阴性杆菌对常用抗菌药物的耐药现象较严重,规范抗菌药物的临床合理应用可能减缓细菌耐药趋势。
OBJECTIVE： To analyze the application of antibiotics and bacterial isolates and the characteristics of drug resistance in our hospital. METHODS： The outbound data of antibiotics were collected from our hospital from 2008 to 2010. Amount ranking and drug frequency ranking were used to analYze the application of antibiotics statistically. RESULTS ： In 3 years, the total amount of antibiotics increased year by year in our hospital, and common clinical isolates were mainly Gram-negative bacilli. Van- comycin-resistant Enterococcus faecalis strains were found out every year, but staphylococcus strains resistant to vancomycin had not appeared. Drug resistance rate of Gram-negative bacilli to antibiotics showed increasing tendency. CONCLUSION： Drug resistance of bacteria is positively related to DDDs of antibiotics. Clinical isolated Gram-negative bacilli to antimicrobial drug resistance are serious relatively, and standardization of clinical rational use of antibiotics may slow down bacterial resistance trends.
出处
《中国药房》
CAS
CSCD
2012年第6期539-542,共4页
China Pharmacy
