摘要
背景:FOXC2在能量代谢等方面发挥重要作用,与脂肪细胞分化密切相关,且FOXC2基因在抵御2型糖尿病及代谢综合征相关因素方面有重要作用。目的:检测云南地区人群大网膜脂肪组织中FOXC2m RNA表达水平,探讨其与2型糖尿病的关系。方法:随机抽取在昆明医学院附属医院行腹部外科手术的2型糖尿病患者及非2型糖尿病患者各50例,RT-PCR检测其大网膜脂肪组织中FOXC2m RNA的表达水平,并分析两组受试者的临床资料与FOXC2m RNA水平的相关性。结果与结论:2型糖尿病患者腹部大网膜脂肪组织FOXC2m RNA表达水平下降;FOXC2m RNA表达水平在2型糖尿病组与空腹血糖、血压呈负相关,在非2型糖尿病组与空腹血糖呈负相关(P<0.01)。提示FOXC2与2型糖尿病的关系主要在于可以减轻胰岛素抵抗,改善胰岛素对糖代谢的调节,此外它的表达下降在糖尿病患者血压升高中起到一定的协同作用。
BACKGROUND： FOXC2 is closely related to the differentiation of adipose cells. It plays an important role in many aspects, such as energy metabolism, resistance of type II diabetes and metabolic syndrome. OBJECTIVE： To investigate the expression level of FOXC2 mRNA in human ventral adipose tissue of Yunnan Province, and to explore the relations between FOXC2 and type II diabetes. METHODS： Type II diabetic patients or nondiabetic patients underwent abdominal surgery in Affiliated Hospital of Kunming Medical University were randomly selected as experimental subjects, with 50 cases in each group. The expression level of FOXC2 mRNA in ventral adipose tissue was detected by RT-PCR. The correlation of FOXC2 mRNA expression and subject clinical data was analyzed. RESULTS AND CONCLUSION： The expression level of FOXC2 mRNA in ventral adipose tissue in type II diabetic patients decreased. The FOXC2 mRNA expression level of diabetic group was inversely related to fasting blood-glucose and blood pressure. The FOXC2 mRNA expression level of nondiabetic group was inversely related to fasting blood-glucose. These findings indicate that FOXC2 may reduce insulin resistance and improve the regulation of insulin on sugar metabolism in type II diabetic patients. In addition, the decrease of FOXC2 expression shows a synergetic effect on blood press raise in diabetic patients.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2011年第50期9496-9500,共5页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
2005云南省教育厅项目(5y0336),《FOXC2基因变异与代谢综合征相关性研究》~~
