摘要
肥胖与肿瘤是全球两大健康问题，肥胖增加肝细胞癌的发病及死亡风险。脂肪组织能够分泌具有多种生物学活性的脂肪因子，如瘦素、脂联素、抵抗素等。近年研究发现脂肪因子在慢性肝脏疾病的纤维化、硬化及癌变中发挥重要作用。本文就脂肪因子与肝细胞癌的研究进展进行综述。
Obesity is rapidly becoming a pandemic and is associated with increased carcinogenesis, especially hepatoceliular carcinoma （HCC）. Adipose tissue has been considered as an endocrine organ because of its capacity to secrete a wide variety of adipokines, such as leptin, adiponectin and resistin. Recently, adipokines have been demonstrated to be associated with many kinds of chronic liver disea ses, liver fibrosis and cirrhosis, and carcinogenesis. Direct evidence supporting the inhibitory and/or activating role of adipokines in the process of carcinogenesis and progression of human HCC has been rapidly accumulating. This review aims to provide important insights into the potential mechanisms of adipokines in the development of HCC. Further investigations will shed light on a new therapeutic target in HCC.
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2012年第1期75-78,共4页
Chinese Journal of Hepatobiliary Surgery
关键词
肝细胞癌
脂肪因子
瘦素
脂联素
抵抗素
Hepatocellular carcinoma
Adipokine
Leptin
Adiponectin
Resistin
