摘要
目的:探讨黄芪注射液治疗缺血性脑卒中的最佳方案。方法:采用L9(4)3正交设计,即黄芪注射液治疗缺血性脑卒中开始应用的时间(A,<3 d、3～7 d、8～12 d),剂量(B,20 mL、40 mL、60 mL),频度(C,2次/d、1次/d、1次/2 d)和疗程(D,15d、20 d、25 d)4因素3水平,以美国国立卫生研究所脑卒中评分确定最佳方案。结果:因素作用主次为A>B>D>C;A、B因素对美国国立卫生研究院卒中量表(NIHSS)的影响有统计学意义(FA=5.537,PA=0.005;FB=4.436,PB=0.015),最佳水平是A1,B3。而C、D因素的作用无统计学意义,从简化临床和经济学角度考虑,C3和D1作为最优水平;优组合为A1B3C3D1。结论:黄芪注射液治疗缺血性脑卒中的最佳方案是发病到开始用药时间<3 d,60 mL/次,1次/2 d,15 d为1疗程。
Objective：To investigate the optical program of Huangqi Injection for the treatment of ischemic stroke.Methods：L9（4）3 orthogonal design was used.That is,the beginning time of applying Huangqi Injection for the treatment of ischemic stroke was（A,〈3 d,3-7 d,8-12 d）,dose（B,20 mL,40 mL,60 mL）,frequency（C,2 times/d,1 time/d,1 time/2d） and treatment（D,15 d,20 d,25 d） 4 factors and 3 levels.The brain stroke score of the U.S.National Institutes of Health was used to determine the optical program.Results：The primary and secondary role of factors was A〉B〉D〉C;the impact of A and B factors on the NIHSS was statistically significant（FA=5.537,PA=0.005;FB=4.436,PB=0.015） and the best level was A1 and B3.The effects of factor C and D had no statistical significance and C3 and D1 were regarded as the optimal level from the clinical and economic point of view;the excellent combination was A1B3C3D1.Conclusion：The optical program of using Huangqi Injection for the treatment of ischemic stroke was that from onset to start medication,the best treatment time was less than 3 d,60 mL pertime one time for two days and 15 d as a course of treatment.
出处
《中医学报》
CAS
2012年第2期215-217,共3页
Acta Chinese Medicine
关键词
脑卒中
黄芪注射液
正交设计
优水平
优组合
stroke
huangqi injection
orthogonal design
superior level
optical combination
