摘要
以茄尼醇为原料与4种不同的酸酐反应,然后再与N-烷羟基-替加氟反应,得到12个新的目标化合物.其结构经IR,1H NMR,MS确认.初步的体外抗肿瘤实验结果表明,目标化合物具有一定抗肿瘤活性.
Twelve diacid solanesyl tegafur esters were synthesized by the reaction of solanesol with four acid anhydrides and N-alkoxy-tegafur.Their chemical structures were confirmed by IR,1H NMR and MS techniques.The preliminary bioassay results show that the target compounds possess antitumor activities to some extent.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2012年第1期169-173,共5页
Chinese Journal of Organic Chemistry
关键词
茄呢醇
替加氟
合成
抗肿瘤活性
solanesol
tegafur
synthesis
antitumor activity
