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顺式阿曲库铵应用于肾功能不全患者麻醉的临床研究进展 被引量:2

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摘要 随着肾功能不全患者接受外科治疗的病例增加,特别是肾移植手术的普及,肾功能不伞患者的麻醉问题越来越受到重视。肾功能不全的患者对药物的排泄清除能力低,保水能力差,同时存在容量的重新分配、pH值的变化等病理情况,这些凶素都会导致血浆胆碱酯酶活性降低,进而引起乙酰胆碱清除率下降,从而引起血浆里游离的肌松药物水平变化,表现为药物持续时间延长、诱导和维持剂量增加及手术后的残余药物效应增加。
出处 《安徽医学》 2011年第12期2086-2088,共3页 Anhui Medical Journal
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