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刺激反应性释药系统的研究进展

Advancementinstimuli-sensitivedrugdeliverysystem
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摘要 刺激反应性释药系统（SSDDS）是一种新型的药物载体。它能够感知人体病理、生理的变化（pH值、温度）或者体外施加的信号（超声、磁信号），然后根据信号变化调节自身的理化性质，进而调控释放其所携带的药物。SSDDS可由水凝胶、脂质体及磁性纳米微球等制备而成。与非刺激反应性释药系统相比，它具有反馈调节，可控性更强，靶向治疗作用更显著等优点。将对近年来刺激反应性释药系统的研究进展作一综述。 Stimuli-sensitive drug delivery system （SSDDS） is an novel drug delivery carrier. It is sensitive to either the internal physiopathologic changes （pH, temperature） of the body or external stimulus signal （ultrasound, magnetic signal） and controls the release of the drugs that it carries according to the variation of physicochemical property which stimulated by the signals. SSDDS can be prepared from hydrogels, liposomes and magnetic nanoparticles. In contrast to non-stimuli-responsive drug delivery system, SSDDS has remarkable advantages including feedback regulation, stronger controllability and targeting therapy. This paper will review the advancement in stimuli-responsive drug delivery system in recent years.
作者 吴贵 郑启新
机构地区 华中科技大学同济医学院附属协和医院骨科
出处 《国际生物医学工程杂志》 CAS 北大核心 2011年第6期367-370,共4页 International Journal of Biomedical Engineering
关键词 智能 水凝胶 磁性脂质体 释药系统 Intelligent Hydrogel Magnetic nanoparticle Drug delivery system
分类号 R318.08 [医药卫生—生物医学工程]
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国际生物医学工程杂志
2011年 第6期

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