摘要
目的探讨卡他莫拉菌(MC)的耐药现状,为临床治疗提供参考依据。方法对临床分离的90株MC采用琼脂稀释法进行抗菌药物敏感试验,并用Nitrocefin纸片检测β-内酰胺酶。结果 MC检出率最高的是儿科占56.7%,其次为呼吸内科占35.6%,肿瘤科占7.7%,MC产β-内酰胺酶率为90.0%;MC对氨苄西林的敏感率最低,仅8.9%;MC对阿莫西林/克拉维酸、左氧氟沙星和克拉霉素100.0%敏感。结论临床医师应选用含β-内酰胺酶抑制剂的青霉素类,第二、三代头孢菌素或大环内酯类治疗MC引起的感染。
OBJECTIVE To approach the antimicrobial resistance of Moraxella catarrhalis（MCA） and provide reference for clinical treatment.METHODS The susceptibility testing was performed for 90 clinical isolates of MCA by agar dilution method.The β-lactamase was detected using nitrocefin disk.RESULTS The detection rate of MCA from department of pediatrics（56.7%） was the highest,followed by department of respiration（35.6%） and department of tumor（7.7%）.90.0% of MCA isolates were β-lactamase producers.Susceptibility rate to ampicillin（8.9%） was the lowest.100.0% of MCA was sensitive to amoxicillin/clavulanic acid,levofloxacin and clarithromycin.CONCLUSION The clinician should use penicillins in combination with β-lactamase inhibitors,second and third generation cephalosporins or macrolides to treat the infection caused by MC.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2012年第2期407-408,共2页
Chinese Journal of Nosocomiology
关键词
卡他莫拉菌
抗菌药物
敏感率
Β-内酰胺酶
Moraxella catarrhalis
Antibiotics
Susceptibility rate
β-lactamase
