摘要
【目的】探讨新生儿缺氧缺血性脑病(hypoxic-ischemic encephalopathy,HIE)患儿外周血生长抑素(soma-tostatin,SS)水平的变化及其与细胞免疫功能的关系。【方法】HIE新生儿50例血SS水平及T淋巴细胞亚群、IL-2、sIL-2R和IL-6分别采用放射免疫分析法、APAAP法和双抗体夹心ELISA法进行检测。并分析两者相关性。【结果】HIE患儿血SS水平明显高于对照组(P<0.01),其细胞免疫功能显示sIL-2R水平明显升高(P<0.01),而CD3+、CD4+百分率、CD4+/CD8+比值、IL-2及IL-6水平明显降低(P均<0.01)。HIE患儿血SS的变化与CD3+、CD4+百分率、CD4+/CD8+比值、IL-2及IL-6水平呈显著负相关(P均<0.01),与sIL-2R呈显著正相关(P<0.01)。【结论】HIE患儿血SS水平升高与HIE存在密切相关,且其变化与机体细胞免疫功能存在非常明显的相关性。
【Objective】 To investigate the changes of plasma somatostatin（SS） and its correlation with cellular immune function in neonates with hypoxic-ischemic encephalopathy（HIE）.【Methods】 Fifty cases of HIE were collected to detect the SS and T lymphocyte subsets,IL-2,sIL-2R as well as IL-6 levels by radioimmunoassay,APAAP and doube antibody sandwith ELISA methods.【Results】 The SS and sIL-2R levels in patients with HIE were significantly higher（P〈0.01）,While the proportion of CD4^＋/CD8^＋,the percentages of CD3^＋ and CD4＋ T subtype and IL-2 as well as IL-6 levels were significantly lower（P〈0.01） than those in control group.The SS levels in patients with HIE had significantly negative corrections with the proportion of CD4^＋/CD8^＋,the percentages of CD3^＋ and CD4^＋ T subtype,IL-2 and IL-6 levels,and a significantly positive corrlation with levels of sIL-2R（P〈0.01）.【Conclusions】 High level of SS is related to HIE,and there is a strong negative correlation between SS and cellular immune function in patients with HIE.
出处
《中国儿童保健杂志》
CAS
北大核心
2012年第1期80-82,共3页
Chinese Journal of Child Health Care
关键词
脑缺血
脑缺氧
生长抑素
免疫
细胞
新生儿
hypoxis-ischemic encephalopathy
somatostatin
immunity
cellular
newborn
