摘要
目的:利用熔融法制备布洛芬Kollidon CL和Kollidon CL-SF固体分散体,提高布洛芬的体外溶出性质。方法:以Kollidon CL和Kollidon CL-SF为载体,利用熔融法制备难溶性药物布洛芬固体分散体,并进行体外溶出研究。采用差示扫描量热分析、粉末X射线衍射分析及扫描电镜观察对制备的固体分散体进行物相鉴别。结果:熔融法制备的布洛芬-Kollidon固体分散体中,布洛芬以无定形态存在,体外溶出速率显著提高,5 min时以Kollidon CL和Kollidon CL-SF为载体的固体分散体中布洛芬累积溶出度是67.1%和67.6%,分别是布洛芬原药的17.8倍和17.9倍。结论:固体分散体技术是提高布洛芬溶出性质的一种有效可行的方法。
OBJECTIVE Solid dispersions （SDs） of ibuprofen （IBU） were prepared with two carriers： Kollidon CL and Kollidon CL-SF, using fusion method in order to improve its dissolution in vitro. METHODS Solid dispersions of ibuprofen were prepared by fusion method and the dissolution characteristics in vitro were studied. Physicochemical properties of the SDs obtained were investigated by differential scanning calorimetry （DSC）, powder X-ray diffraction （PXRD）, scanning electron microscope （SEM）. RESULTS IBU changed to an amorphous form in the SDs with the two carriers using the fusion method. The dissolution rate of IBU in the SDs was markedly enhanced. The dissolution test showed that after 5min of dissolution, the concentrations of IBU in the SDs with Kollidon CL and Kollidon CL-SF as the carrier were 67.1 % and 67. 6%, corresponding to 17. 8 and 17. 9 times that of the pure IBU. CONCLUSION It was demonstrated that solid dispersion method was very useful to improve the dissolution characteristics of IBU.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2012年第1期22-26,共5页
Chinese Journal of Hospital Pharmacy
关键词
固体分散体
布洛芬
溶出度
solid dispersions
ibuprofen
dissolution
