摘要
目的观察骨化三醇对慢性肾衰肾性骨病的治疗疗效。方法对25例肾性骨病患者予以治疗基础疾病、透析(血液透析或腹膜透析)、口服补充钙剂,同时加口服骨化三醇治疗,持续治疗3个月,对比治疗前后患者的血清钙、磷、甲状旁腺素、碱性磷酸酶、肾功能等指标变化。结果 25例患者经治疗3个月后,血清钙、甲状旁腺素比治疗前升高,血清磷下降,治疗前后比较差异有统计学意义(P<0.05),血清碱性磷酸酶、血尿素氮及血清肌酐变化不明显。结论在肾性骨病患者中应用骨化三醇治疗,可明显升高血钙,降低血磷及甲状旁腺素,对肾功能变化无不利影响。
Objective To observe clinical treatment of renal osteodystrophy in chronic renal failure using calcitriol.Methods To treat 25 patients with renal osteodystrophy in our hospital for 3 months by treat underlying disease,dialysis（hemodialysis or peritoneal dialysis）,oral calcium,while plus oral calcitriol treatment.Then detect the level of serum calcium,phosphorus,parathyroid hormone,alkaline phosphatase and renal function,and compare them with before treatment.Results The level of serum calcium after treated was significantly higher than that of before treatment.The level of serum phosphorus and parathyroid hormone after treated was significantly lower than that of before treatment（P0.05）.and the level of serum alkaline phosphatase,blood urea nitrogen and serum creatinine did not change significantly.Conclusion Calcitriol can increase the serum calcium level in chronic renal failure patient with renal osteodystrophy.Calcitriol can reduced the serum phosphorus and parathyroid hormone level in chronic renal failure patient with renal osteodystrophy,and no adverse effect on patient＇s renal function.
出处
《当代医学》
2012年第3期135-136,共2页
Contemporary Medicine
关键词
慢性肾衰
肾性骨病
骨化三醇
治疗
Chronic renal failure
Renal osteodystrophy
Calcitriol
Therapy
