摘要
目的：探讨H-FABP（心肌型脂肪酸结合蛋白）与GPBB（糖原磷酸化酶同工酶）在临床早期诊断急性心肌梗死（AMI）的应用指标及实用价值。方法：选取48例正常人与42例急性心肌梗死病人采用用双抗体夹心ELISA法对急性胸痛的病人在0～1h、1～3h、3～6h内快速检测H—FABP与GPBB。结果：本实验研究结果表明H—FABP、GPBB、MB、CK—MB、eTnI在0～1h的敏感性分别为38．10％、35．71％、3．62％、0，在1～3h分别为85．71％、83．33％、61．90％、33．33％、23．81％，在3～6h分别为100％、100％、90．48％、61．90％、57．14％f其特异性O～1h分别为100oA、100％、100％、100％、100％，其1～3h特异性分别为100oA、100％、91．67oA、97．92oA、97．92％，其3～6h特异性分别为100％、100％、87．5％、95．83％、95．83％。具有统计学意义（P〈0．05）。结论：从三组数据结果之中分析可知H—FABP与GPBB敏感性及特异性明显优于MB、CK—MB和eTnI,尤其在1～3h内H—FABP与GPBB对早期诊断AMI更具有诊断价值。
Objective ： To Probe into the role of H- FABP （Heart- type fatty acid binding protein） And GPBB （Glycogen phosphorylase isoenzyme） in the early diagnosis of acute myocardial infarction （AMI）,and the value of these markers in clinical application. Methods： The experiment included 48 controls and 42 AMI patients. The levels of H--FABP and GPBB were measured by Double＇antibody sandwich ELISA at 0～1h, 1～3h and 3～6h. Results： The sensitivity of H--FABP, GPBB, MB, CK--MBc and TnI. at 0～1h was 38.10%, 35.71%, 3.62%, 0 and 0, at 1～3h 85.71%,83. 33%,61.90%, 33.33%and 23.81%, and at 3 ～6h.100%, 100%, 90. 48%, 61. 90% and 57. 14%. The specificity was 100%, 100%, 100%, 100% andl00% at 0～1h, 100%, 100%,91.67%, 97.92% and 97. 92% at 0～3h and 100%, 100%, 87.5%, 95. 83% and 95.83% at 3～6h, with a significant difference （P 〈0.05）. Conclusion：The data analysis of these three sets show the superior sensitivity and specificity of H--FABP and GPBB over MB, CK--MB and cTnI at 1～3h in the early diagnosis of AMI .
出处
《黑龙江医药科学》
2011年第6期23-24,共2页
Heilongjiang Medicine and Pharmacy
关键词
心肌型脂肪酸结合蛋白
糖原磷酸化酶同工酶
急性心肌梗死
心肌损伤标记物
heart-type fatty acid binding protein
glycogen phosphorylase isoenzyme
acute myocardialinfarction
markers of myocardial injury
