摘要
目的探讨丁苯酞对重度颈内动脉颅内段狭窄患者脑血管反应性（cerebrovascular reactivity，CVR）的影响。方法将2010年1月至2010年11月期间南京卒中注册系统中经脑血管造影确诊为颈内动脉颅内段重度狭窄的患者，随机分为丁苯酞组和对照组。所有患者均给予符合指南规定的缺血性脑血管病治疗药物，丁苯酞组加用丁苯酞（20mg，3次／d）。所有患者均在治疗前采用经颅多普勒和CO2吸人激发试验评价患者CVR，并在治疗后3个月复查。结果81例患者符合纳入标准，失访11例（13．6％），最终有70例纳入分析，丁苯酞组和对照组各35例。患者平均年龄（55．2±9．0）岁，男性47例，女性23例，血管狭窄程度为72％～99％，平均79．4％±9．5％。治疗3个月后，丁苯酞组CVR显著改善（P=0．007），而对照组改善不显著（P=0．330）。服药期间所有患者均未发生缺血性卒中事件，丁苯酞组未发生严重不良反应。结论丁苯酞可改善重度颈内动脉颅内段狭窄患者的CVR。
Objective To investigate the effect of butylphthalide on cerebrovascular reactivity （CVR） in patients with severe intracranial internal carotid stenosis. Methods The patients with severe intracranial internal carotid stenosis diaguosed by cerebral angiography in Nanjing Stroke Registry Program from January 2010 to November 2010 were randomly divided into either the butylphthalide group or the control group. All patients received the oral drugs for ischemic cerebrovascular disease that met the guideline criteria, and butylphthalide 20 mg 3 times a day orally was added in the butylphthalide group. The CVR was evaluated by transcranial Doppler and CO2 inhalation challenge test, and reexamined 3 months after treatment. Results A total of 81 patients met the inclusion criteria, 11 （13.6%） were lost to follow-up, and finally 70 （n =35 in each group） were included in the analysis. The mean age of the patients was 55.2±9. 0 years, 47 of them were male and 23 were female. The degree of vascular stenosis was 72% to 99% （mean 79.4%± 9. 5% ）. The CVR was improved significantly after 3 months oftreatment in the butylphthalide group than that in the control group （P = 0. 007）, but it was not improved significantly in the control group （P =0. 330）. All the patients did not have ischemic stroke events during the medication. No serious adverse reactions occurred in the butylphthalide group. Conclusions Butylphthalide may improve the CVR in patients with severe intraeranial internal carotid stenosis.
出处
《国际脑血管病杂志》
北大核心
2011年第11期824-828,共5页
International Journal of Cerebrovascular Diseases
基金
国家自然科学基金（81000501）
江苏省自然科学基会（BK2010067）
关键词
3-n-丁苯酞
颈动脉狭窄
脑缺血
脑血管障碍
血管舒缩系统
超声检查
多普勒
经颅
3-n-Butylphthalide
Carotid stenosis
Brain ischernia
Cerebrovasculardisorders
Vasomotor system
Ultrasonography, Doppler, transcranial
