摘要
结直肠癌（Colorectal Cancer,CRC）是世界上发病率最高的恶性肿瘤之一.CRC的发生与细胞的跨膜信号转导系统功能异常有关,目前已经明确Ras/Raf/MAPK级联反应通路在其中起到很重要的作用.在CRC中,KRAS基因突变十分常见,KRAS基因的突变使信号转导通路下游各种基因的激活不再依赖于表皮生长因子受体（Epidermal Growth Factor Receptor,EGFR）的启动,这对CRC的发生、发展、治疗与预后起着非常重要的作用.因此,在临床工作中,检测KRAS基因突变情况显得尤为重要,这也对检测技术及其准确性提出了更高的要求.本文对KRAS在CRC中的作用、机制及其突变的概率、检测方法做一简要综述.
Colorectal cancer is one of the most common malignancies in the world. Abnormal function of intestinal cells＇ transmembrane signal transduction systems is associated with colorectal carcinogenesis,of which Ras/Raf/Mitogen -activated protein kinase （MAPK）cascade has been definitely and significantly involved. KRAS gene mutation leads the epidermal growth factor receptor（EGFR） ＇s initiation unnecessary for the activation of va- rious genes in the downstream signal transduction pathways, which plays a major role in colorectal cancer＇s genesis, progress therapy and prognosis. Therefore, testing KRAS gene status is essential in the clinical work, which demands for more precise of these processes. We sum up KRAS gene＇s role in colorectal cancer and its mechanism, mutant incidence and testing methods.
出处
《实用肿瘤学杂志》
CAS
2011年第6期579-583,共5页
Practical Oncology Journal
