摘要
利用张恒贵等人构造的兔子窦房结细胞实验模型,通过仿真模拟研究了窦房结中突触素的含量对窦房结膜电压的影响.模拟结果发现,一方面利用该模型可以重现有生理缺陷的窦房结异常搏动现象,这与临床上观察到的,老年人或者长期酗酒者的心脏因窦房结中突触素含量减少导致窦房结不能正常起搏,甚至心脏猝死现象相吻合;另一方面,通过模拟对比分析发现,突触素含量降低的影响主要表现在两个方面,降低钙离子通道的导电性能,减少乙酰胆碱的分泌,这两种影响都直接导致窦房结细胞的振动性能的降低.以上结果将有助于揭示窦房结中突触素减少与心脏体系的异常起搏之间的内在联系,并对预防和诊断心源性猝死或病态窦房结综合症提供一定的理论帮助.
By using an experiment model of SA node cell in the rabbit heart, which proposed by Zhang et al, the effect of the content of synaptophysin in SA node on transmembmne voltage of SA node is investigated by computer simulation. The results show, on one hand, using this model, it can be reproduced the phenomenon of abnormal rhythm in heart with physiological defect, and these results are consistent with those clinical phenomena, such as abnormal pacemaking or even sudden cardiac death, which induced by reduction of synapsin content in sinus node for elders or chronic alcoholics heart. On the other hand, the decrease of synapsin may influence the SAN in two aspects mainly, weakening the conductive activity of calcium ion channel, and reducing the secretion of acetylcholine, and these two effects directly reduce SAN ＇ s oscillation capability. These results will help to reveal the internal connection, between the decrease of synaptophysin in the sinoatrial node and abnormal pacemaking in complex cardiac system. And provide a theoretical guidance for the clinical diagnosis of angiocardiopathy, such as, sudden cardiac death and sick sinus syndrome.
出处
《安徽师范大学学报（自然科学版）》
CAS
北大核心
2011年第6期537-541,共5页
Journal of Anhui Normal University(Natural Science)
基金
国家自然科学基金理论物理专款项目(11047017)
安徽省自然科学基金(2009KJ099B)
安徽师范大学创新团队科研基金
威康信托基金Wellcome Trust(081808/Z/06/Z)
英国生物工艺科学研究基金BBSRC(BBS/B1678X)
关键词
突触素
窦房结
仿真模拟
异常搏动
synaptophysin
sinoatrail node
simulation
abnormal pacemaking
