摘要
目的探讨生存素(Survivin)、Ki-67核抗原在宫颈癌和宫颈上皮内瘤变(CIN)中的表达及生物学意义。方法采用免疫组化S-P法,检测26例宫颈癌,78例宫颈上皮内瘤变(CINⅠ28例,CINⅡ23例,CINⅢ27例)及12例正常宫颈组织中Survivin、Ki-67的表达水平。结果 Survivin、Ki-67核抗原在正常宫颈组织、CIN及宫颈癌中的表达依次递增,Ki-67核抗原的表达随Survivin表达增加而上升,统计学上差异有显著意义(P<0.05)。结论 Survivin、Ki-67核抗原在宫颈癌中的异常表达,可能与宫颈癌发生、发展过程中凋亡抑制和增殖能力增强有关。
Objective To investigate the expression and the biological significance of Survivin,Ki-67 in the cervical carcinoma and the cervical intraepithelial neoplasia（CIN）.Methods Immunohistochemical technique was used to detect the expression of regulators Survivin and Ki-67 in 26 case of cervical carcinoma,78 case of cervical intraepithelial neoplasia（CINⅠ28例,CINⅡ23例,CINⅢ27例）and 12 case of normal cervical tissures.Results Expressions of Survivin and Ki-67 nuclear antigen in normal cervical tissures,CIN and cervical carcinoma were gradually increased（P0.05）.The expression of Ki-67 was increased with the increment of Survivin expression（P0.05）.Conclusion The abnormal expression of Survivin and Ki-67 nuclear antigen with cervical carcinoma,may be relate with the cell apoptosis and poliferation.
出处
《中国实验诊断学》
北大核心
2011年第12期2067-2069,共3页
Chinese Journal of Laboratory Diagnosis
