摘要
目的：既往的研究表明幽门括约肌的收缩与舒张受胆碱能神经、肾上腺素能神经、多肽能神经和NOS神经的调节。本研究探讨幽门松弛与胆汁返流的关系及肠血管活性肽（VIP）和一氧化氮（NO）对幽门松弛的影响。方法：通过胃镜检查把幽门功能分为3组：幽门松弛组、幽门运动组、幽门闭合组。测定胃液中的甘胆酸和pH值及作胃窦粘膜病理检查，了解3组患者的十二指肠胃返流情况，并取幽门局部粘膜，测定其VIP和NO含量。结果：幽门松弛组十二指肠胃返流率为55.6%，明显高于幽门运动组和幽门闭合组。幽门松弛组局部粘膜NO的含量明显高于其它组，而3组间VIP的含量无显著差别。结论：幽门松弛是胆汁返流的主要原因，局部NO增高是幽门松弛的重要原因。
Purpose: Some studys had show that pylorus stenosis is due to the absent of NOS and Vasoactive intestinal peptide(VIP) nerv es in pylorus sphincter, in this study. We evaluated the relationship between pylorus relaxation and duodenogastric reflux and the relations hip between the pylorus relaxation state and local mucosa VIP and NO content. Methods: Patients with chronic gastritis were divided into t hree groups: (1) pylorus relaxation group, (2)pylorus motion group,( 3) pylorus closing group according to endoscopic examination. Glycocholic acid and pH were measure in gastric fluid to determine weather ther e is bile reflux or not. Pylorus local mucosa were obtained to surve y their VIP and NO content. Results: The rate of bile reflux in pyl orus relaxation group is 55.6%, that is higher compare with the other two group (17.6% and 20.0%). Mucosa NO in pylorus relaxation group is 1.212±0.240 μmol/g, higher compare with that in others (0.904±0 .085 and 0.954±0.103 μmol/g). But the mucosa VIP content in the thr ee groups is 0.877±0.339, 0.733±0.323 and 0.732±0.288 ng/mg, there i s no statistic difference. Conclusion: Pylorus relaxation is the import ant cause of the duodenogastric reflux. NO increasing is one of the important causes of pylorus relaxation.
出处
《临床消化病杂志》
2000年第1期13-15,共3页
Chinese Journal of Clinical Gastroenterology
