摘要
为探讨中药对骨性关节炎氧自由基代谢的影响 ,采用 Hulth方法复制出家兔膝骨关节炎模型并随机分为模型组、芬必得组和中药逐痹汤组。均于治疗 1个月后测定红细胞超氧化物歧化酶 (SOD)活性及血清脂质过氧化物 (L PO)含量 ,并做统计学分析。结果显示逐痹汤组动物的 SOD活性显著高于其他两组 ,而 L PO含量显著低于其他两组 (P<0 .0 1) ,模型组与芬必得组无显著性差异 (P>0 .0 5 )。认为逐痹汤可显著提高 SOD的活性 ,降低 L PO含量 ,从而起到延缓关节软骨的退变 。
In order to explore the influence of traditional Chinese drugs (TCD) on the metabolism of oxygen free radical in osteoarthritis, rabbit models of knee osteoarthritis were made by Hulths method and randomly divided into three groups: Groups Ⅰ, Ⅱ and Ⅲ, which were treated by nothing, Fenbid and “ZHUYU TANG” (ZYT, TCD Decoction Activating Blood Flow and Removing Blood Stasis), respectively. One month after the treatment, the erythrocytic SOD activities and the plasma LPO levels of the three groups were measured and statistically analysed. The results showed that the SOD activity of Group Ⅲ was much higher , while the LPO level was much lower, than those of the other two groups (P < 0.01) and there was no significant difference between Group Ⅰ and Group Ⅱ (P < 0.05). It was considered that ZYT functions to improve SOD activity and to lower LPO level significantly and thus to delay the degeneration of joint cartilage and to accelerate the cartilage repair.
出处
《中医正骨》
2000年第1期8-9,共2页
The Journal of Traditional Chinese Orthopedics and Traumatology
关键词
膝关节骨性
关节炎
中医药疗法
氧自由基代谢
knee osteoarthritis/TCM therapy metabolism/drug action experimental study animal rabbit
