期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

高血压患者平均血小板体积和血清高敏C反应蛋白水平的变化及相关关系 被引量：5

原文传递
导出
摘要 目的观察高血压患者平均血小板体积(MPV)和血清高敏C反应蛋白(hsCRP)水平的变化及相关关系。方法单纯原发性高血压患者106例和健康对照22例,测定MPV、血清hsCRP和尿微量白蛋白。微量白蛋白尿(MAU)的定义是尿微量白蛋白>19mg/L。根据尿微量白蛋白结果将高血压患者分为非MAU亚组79例和MAU亚组27例。结果与对照组比较,高血压组MPV升高[(9.69±1.23)比(9.09±1.24)fL,P<0.05],血清hsCRP升高。与对照组和非MAU亚组比较,MAU亚组MPV升高[(10.16±0.92)比(9.09±1.24),(9.53±1.30)fL,均P<0.05],血清hsCRP升高。Spearman相关显示,高血压组MPV与血清hsCRP呈正相关(r=0.32,P<0.01),MAU亚组MPV与血清hsCRP呈正相关(r=0.43,P<0.05)。结论高血压患者MPV和血清hsCRP水平明显升高,且两者之间呈正相关,伴MAU者这些变化更明显。
作者 许文亮 徐莉 王旭 邵一兵
机构地区 青岛市市立医院心内科
出处 《中华高血压杂志》 CAS CSCD 北大核心 2011年第11期1080-1082,共3页 Chinese Journal of Hypertension
关键词 高血压 平均血小板体积 高敏C反应蛋白 尿微量白蛋白
分类号 R544.1 [医药卫生—心血管疾病]
  • 相关文献

参考文献19

  • 1Varol E, Akcay S, Icli A, etal. Mean platelet volume in patients with prehypertension and hypertension[J]. Clin Hemorheol Microcirc,2010,45(1) :67-72.
  • 2Coban E, Yazicioglu G, Berkant Avci A, etal. The mean platelet volume in patients with essential and white coat hypertension[J]. Platelets, 2005,16 (8) : 435-438.
  • 3Boos CJ, Beevers GD, Lip GY. Assessment of platelet activation indices using the ADVIATM 120 amongst "high-risk' patients with hypertension[J]. Ann Med, 2007,39 (1) : 72-78.
  • 4Inanc T, Kaya MG, Yarlioglues M, etal. The mean platelet volume in patients with non-dipper hypertension compared to dippers and normotensives[J]. Blood Press, 2010,19 (2) : 81-85.
  • 5Kaya MG, Yarlioglues M, Gunebakmaz O, et al. Platelet activation and inflammatory response in patients with non-dipper hypertension[J]. Atherosclerosis,2010,209 (1) :278-282.
  • 6Preston RA, Coffey JO,. Materson BJ, et al. Elevated platelet Pselectin expression and platelet activation in high risk patients with uncontrolled severe hypertension[J]. Atherosclerosis, 2007, 192(1) : 148-154.
  • 7汪迎春,李南方,王新玲,祖菲亚,曹梅,骆秦,孔剑琼,周克明.高血压合并阻塞性睡眠呼吸暂停低通气综合征患者高敏C反应蛋白的研究[J].心血管康复医学杂志,2011,20(3):217-220. 被引量：6
  • 8张争鸣.高血压患者血清白细胞介素-18和C反应蛋白水平检测的临床意义[J].心血管康复医学杂志,2010,19(6):621-623. 被引量：2
  • 9Schillaei G, Pirro M, Gemelli F, et al. Increased C-reactive protein concentrations in never-treated hypertension: the role of systolic and pulse pressures[J]. J Hypertens, 2003, 21(10) :1841-1846.
  • 10Chae Claudia, Lee R, Rifai N, et al. Blood pressure and inflammation in apparently healthy men[J]. Hypertension,2001,38(3) : 399-403.

二级参考文献20

  • 1无,龚兰生,许玉韵,张维忠,刘望彭,王新房,王宏宇,张瑞岩,郭远,李运田,马志敏,芦娜,倪永斌,王敏,杨娅,何建国,高旭光,丁康,沈晨阳,陈生龙,史旭波,陶军.中国血管病变早期检测技术应用指南(第一次报告)[J].中国民康医学,2006,18(9):323-331. 被引量：94
  • 2钟丽华,赵环宇,崔艳.冠心病患者血清白细胞介素18的检测及其临床意义[J].中国动脉硬化杂志,2007,15(1):50-50. 被引量：2
  • 3Gerdes N,Sukhova GK,Libby P,et al.Expression of interleukin(IL)-18 and functional IL-18 receptor on human vascular endothelial cells,smooth muscle cells,and macrophages:implications for atherogenesis[J].J Exp Med,2002,195(2):245-257.
  • 4Blankenberg S,Tiret L,Bickel C,et al.Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina[J].Circulation,2002,106(1):24-30.
  • 5Yosef Levi IM,Grad E,Danenberg HD.C-reactive protein and atherothrombosis:a prognostic factor or a risk factor[J].Harefuah,2007,146(12):970-974,996.
  • 6Mahadik SR,Deo SS,Mehtalia SD.Association of adiposity,inflammation and atherosclerosis:the role of adipocytokines and CRP in Asian Indian subjects[J].Metab Syndr Relat Disord,2008,6(2):121-128.
  • 7Ridker PM.C-reactive protein and the prediction of cardiovascular events among those at intermediate risk:moving an inflammatory hypothesis toward consensus[J].J Am Coll Cardiol,2007,49 (21):129-138.
  • 8Hein H.Cardiovascular diseases and sleep disordered breathing[J].Pneumologie,2004,58(7):505-509.
  • 9McNicholas WT,Bonsignore MR.Sleep apnoea as an independent risk factor for cardiovascular disease:current evidence,basic mechanisms and research priorities[J].Eur Respir J,2007,29:156-178.
  • 10Hatipoglu U,Rubinstein I.Inflammation and obstructive sleep apnea syndrome:how many ways do I look at them?[J].Chest,2004,126:1-2.

共引文献6

同被引文献86

  • 1李建军.高血压可能是一种炎症相关性疾病[J].高血压杂志,2005,13(9):526-527. 被引量：46
  • 2吕萍,李自成,常青.高血压病患者C反应蛋白变化的临床意义[J].第二军医大学学报,2005,26(9):1034-1036. 被引量：25
  • 3闫东来,寇丽,于泳浩.异丙酚对脂多糖诱导大鼠腹腔巨噬细胞Toll样受体-4mRNA表达的影响[J].中华麻醉学杂志,2007,27(2):149-151. 被引量：6
  • 4伍章保,王汀,刘青云,陈礼明.赤芍总苷抗凝血作用机制研究[J].安徽中医学院学报,2007,26(3):39-42. 被引量：13
  • 5Kuklinska AM, Mroczko B, Musial WJ, et al. High-sensitivity C reactive protein and total antioxidant status in patients with es- sential arterial hypertension and dyslipidemia [J]. Adv Med Sci, 2009, 54 (2): 225-232.
  • 6Kuklinska A M,Mroczko B. High-sensitivity C-reactiveprotein and total antioxidant status in patients with es-sential arterial hypertension and dyslipidemia [ J]. AdvMed, 2009 , 54(2) : 225-232.
  • 7Charbonneau F, Anderson T J, Title L, et al. Modula-tion of arterial reactivity using amlodipine and atorvastatin measured by ultrasound examination [ J ] . Atheroscle-rosis, 2008,197(1) : 420 - 427.
  • 8Ridker P M. High-sensitivity C-reactive protein : poten-tial adjunct for global risk assessment in the primary pre-vention of cardiovascular disease [ J ]. Criculation,2011,103: 1813-818.
  • 9FUJIHARA C, WILLIAMS J A, WATANABE M, et al. T cell-B cell thymic cross-talk:maintenance and function of thymic B cells requires cognate CD40-CD40 ligand interaction [ J 1. J Immunol, 2014,193 ( 11 ) : 5534-5544.
  • 10NANNIZZI-ALAIMO L, ALVES V L, PHILLIPS D R. Inhibitory effects of glycoprotein IIb/IIIa antagonists and aspirin on the release of soluble CD40 ligand during platelet stimulation[ J ] .Circulation, 2003,107 : 1123-1128.

引证文献5

二级引证文献72

中华高血压杂志
2011年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部